SITARA M 50/1000 10S

About

SITARA M 50/1000 is a combination medication containing Sitagliptin (50mg) and Metformin (1000mg), indicated for the management of type 2 diabetes mellitus in adults. Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, works by enhancing the body's natural ability to lower elevated blood glucose levels. It achieves this by increasing the active levels of incretin hormones, which stimulate insulin release from the pancreas and suppress glucagon secretion in a glucose-dependent manner. Metformin, a biguanide, primarily reduces hepatic glucose production and improves insulin sensitivity in peripheral tissues.

This higher-dose combination is often used when lower doses or monotherapy have not achieved adequate glycemic control. It provides a potent synergistic effect to manage blood sugar effectively, helping to reduce HbA1c levels and mitigate the risk of diabetes-related complications, especially when diet and exercise alone are insufficient.

Uses

• Treatment of type 2 diabetes mellitus.
• To achieve better blood sugar control.
• Used when diet and exercise are insufficient.
• As an add-on to other antidiabetic therapies.

Directions For Use

Take orally with meals, usually once or twice daily, as prescribed by your doctor.

Benefits

• Potent reduction in HbA1c.
• Effective control of fasting and post-meal glucose.
• Low risk of hypoglycemia.
• May aid in modest weight management (metformin).
• Improves insulin action and secretion.
• Convenient fixed-dose combination.

Side Effects

• Nausea
• Diarrhea
• Abdominal discomfort
• Headache
• Upper respiratory tract infection
• Nasopharyngitis
• Joint pain
• Pancreatitis (rare)
• Kidney problems (rare)
• Lactic acidosis (rare, metformin)
• Vitamin B12 deficiency (metformin)
• Allergic reactions

Safety Measures

• Alcohol - Limit alcohol intake due to increased risk of lactic acidosis with metformin.
• Pregnancy - Not recommended during pregnancy; consult a doctor for suitable alternatives.
• Breastfeeding - Not advised during breastfeeding; seek medical advice.
• Liver - Contraindicated in severe liver impairment due to the metformin component.
• Kidney - Contraindicated in severe kidney impairment; dose adjustment needed for moderate impairment.
• Lung - Use with caution in severe respiratory conditions due to potential for lactic acidosis.

Disclaimer

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