Sitared-MD XR 100/10/500 Tablet

About

Sitared-MD XR 100/10/500 Tablet is a sophisticated extended-release oral medication designed for the comprehensive management of Type 2 Diabetes Mellitus. This triple-combination therapy typically comprises Sitagliptin (a DPP-4 inhibitor), an SGLT2 inhibitor like Dapagliflozin, and Metformin (a biguanide). Sitagliptin works by enhancing the body's natural incretin hormones, which increase insulin release and decrease glucagon secretion in a glucose-dependent manner, thereby improving glycemic control. Dapagliflozin, an SGLT2 inhibitor, reduces glucose reabsorption in the kidneys, leading to increased urinary glucose excretion and lower blood glucose levels, while also offering cardiovascular and renal benefits.

Metformin, the cornerstone of diabetes treatment, primarily reduces hepatic glucose production and improves insulin sensitivity in peripheral tissues, leading to decreased glucose absorption from the gastrointestinal tract. The extended-release formulation ensures a sustained therapeutic effect, contributing to better adherence and smoother glucose control throughout the day. This synergistic combination addresses multiple pathophysiological defects of Type 2 Diabetes, providing robust glycemic reduction and potentially mitigating long-term complications when used as an adjunct to diet and exercise.

Uses

• Management of Type 2 Diabetes Mellitus
• Improvement of glycemic control
• Adjunct to diet and exercise regimen
• Reduction of HbA1c levels

Directions For Use

Take one tablet orally once daily with a meal, preferably in the evening. Swallow the tablet whole; do not crush, chew, or break it.

Benefits

• Comprehensive blood sugar control
• Reduces HbA1c effectively
• Offers cardiovascular and renal benefits
• Convenient once-daily dosing
• Improves insulin sensitivity
• Aids in weight management (SGLT2 component)

Side Effects

• Nausea
• Diarrhea
• Abdominal pain
• Headache
• Upper respiratory tract infection
• Urinary tract infection
• Genital yeast infection
• Hypoglycemia (low blood sugar)
• Lactic acidosis (rare, serious)
• Dehydration
• Dizziness
• Joint pain
• Pancreatitis (rare)

Safety Measures

• Alcohol - Avoid excessive alcohol consumption due to an increased risk of lactic acidosis, especially with the Metformin component.
• Pregnancy - Not recommended during pregnancy. Consult your doctor; insulin is generally preferred for glycemic control in pregnant women.
• Breastfeeding - Not recommended. Components may pass into breast milk. Consult your doctor.
• Liver - Use with caution. Metformin is contraindicated in severe hepatic impairment due to increased risk of lactic acidosis.
• Kidney - Contraindicated in severe renal impairment. Dose adjustment is necessary for moderate impairment due to Metformin and SGLT2 inhibitor components.
• Lung - Use with caution in patients with severe respiratory conditions due to the potential for lactic acidosis.

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