GLEDEPA MET XR 1GM 7

About

This medication is a combination product containing Glimepiride and Metformin Extended Release (XR), designed for the effective management of type 2 diabetes mellitus. Glimepiride, a sulfonylurea, acts by stimulating insulin secretion from the pancreatic beta cells, thereby directly lowering blood glucose levels. Metformin XR, a biguanide, primarily reduces hepatic glucose production and improves insulin sensitivity in peripheral tissues, with the extended-release formulation allowing for once-daily dosing and potentially reduced gastrointestinal side effects compared to immediate-release metformin. This combination is indicated for adults with type 2 diabetes when diet, exercise, and monotherapy with either agent do not provide adequate glycemic control, offering sustained blood sugar management throughout the day and helping to achieve target HbA1c levels.

Uses

• Treatment of type 2 diabetes mellitus.
• Improvement of glycemic control.
• When diet and exercise are insufficient.
• As an adjunct to lifestyle modifications.

Directions For Use

Take orally once daily with the evening meal. Swallow the tablet whole; do not crush, chew, or break it.

Benefits

• Provides sustained blood sugar control.
• Reduces hepatic glucose production.
• Enhances insulin sensitivity.
• Stimulates insulin release.
• Convenient once-daily dosing.
• May reduce gastrointestinal side effects compared to immediate-release metformin.

Side Effects

• Hypoglycemia
• Nausea
• Diarrhea
• Abdominal discomfort
• Metallic taste
• Headache
• Dizziness
• Weight gain
• Lactic acidosis (rare)
• Vitamin B12 deficiency
• Skin rash
• Photosensitivity

Safety Measures

• Alcohol - Avoid excessive alcohol intake as it can increase the risk of hypoglycemia and lactic acidosis, especially with metformin.
• Pregnancy - Generally not recommended during pregnancy; insulin therapy is often preferred for glycemic control in pregnant women with diabetes.
• Breastfeeding - Not recommended during breastfeeding as both components may pass into breast milk and could cause hypoglycemia in the infant.
• Liver - Contraindicated in severe hepatic impairment due to increased risk of lactic acidosis (metformin) and prolonged drug effects (glimepiride).
• Kidney - Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²) due to the risk of metformin accumulation and lactic acidosis.
• Lung - Use with caution in conditions causing hypoxia (e.g., severe respiratory failure) as it may increase the risk of lactic acidosis.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.