TEBINA 250MG TAB

About

Terbinafine 250mg, often found as TEBINA 250MG TAB, is an allylamine antifungal agent primarily used to treat dermatophyte infections of the skin, hair, and nails. It exerts its fungicidal action by inhibiting squalene epoxidase, a key enzyme in the fungal ergosterol biosynthesis pathway. This inhibition leads to an accumulation of squalene within the fungal cell and a deficiency of ergosterol, both of which are toxic to the fungal cell, ultimately leading to fungal cell death. Its potent fungicidal activity makes it highly effective against a broad spectrum of dermatophytes, including *Trichophyton*, *Microsporum*, and *Epidermophyton* species.

Oral terbinafine is particularly effective for onychomycosis (fungal nail infections) due to its ability to penetrate the nail plate and achieve fungicidal concentrations. It is also indicated for severe tinea infections that are extensive, debilitating, or unresponsive to topical therapy. The drug is extensively metabolized in the liver and primarily excreted via urine. Patients undergoing prolonged therapy should be monitored for liver function to ensure safety and efficacy.

Uses

• Treatment of onychomycosis (fungal nail infections)
• Management of tinea corporis (ringworm of the body)
• Therapy for tinea cruris (jock itch)
• Treatment of tinea pedis (athlete's foot)

Directions For Use

Take one tablet orally once daily with or without food, as directed by your physician. Complete the full course of treatment even if symptoms improve to prevent recurrence.

Benefits

• Highly effective against dermatophyte infections
• Fungicidal action for complete eradication of fungi
• Effective for difficult-to-treat nail infections
• Can be used for extensive skin fungal infections
• Generally well-tolerated by most patients
• Available in oral form for systemic treatment

Side Effects

• Headache
• Nausea
• Diarrhea
• Abdominal pain
• Dyspepsia
• Rash
• Urticaria
• Taste disturbance (dysgeusia)
• Liver enzyme elevation
• Arthralgia (joint pain)
• Myalgia (muscle pain)
• Fatigue

Safety Measures

• Alcohol - Avoid or limit alcohol consumption during treatment due to the potential for increased risk of liver damage, as terbinafine is metabolized by the liver.
• Pregnancy - Terbinafine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult a doctor.
• Breastfeeding - Terbinafine is excreted in breast milk. Therefore, breastfeeding is not recommended during treatment with this medication.
• Liver - Contraindicated in patients with chronic or active liver disease. Liver function tests should be performed before and during treatment.
• Kidney - Use with caution in patients with renal impairment (creatinine clearance <50 mL/min); dose reduction may be necessary.
• Lung - No specific precautions are generally required for patients with lung conditions, as terbinafine does not typically affect respiratory function.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.