TEBINA 500MG TAB

About

Terbinafine 500mg is an antifungal medication belonging to the allylamine class, primarily used to treat fungal infections of the skin, hair, and nails. It works by inhibiting squalene epoxidase, a key enzyme in the fungal ergosterol biosynthesis pathway. This inhibition leads to an accumulation of squalene within the fungal cell and a deficiency of ergosterol, both of which are toxic to the fungal cell membrane, ultimately causing fungal cell death. Terbinafine is highly lipophilic and keratophilic, allowing it to concentrate in the skin, nails, and fatty tissues, providing sustained antifungal activity.

Uses

• Treatment of onychomycosis (fungal nail infections).
• Management of tinea capitis (ringworm of the scalp).
• Severe tinea corporis (ringworm of the body).
• Extensive tinea cruris (jock itch) unresponsive to topical therapy.

Directions For Use

Take one tablet orally once daily, with or without food, as directed by your physician. Complete the full course of treatment.

Benefits

• Highly effective against dermatophytes.
• Achieves high concentrations in skin and nails.
• Provides sustained antifungal activity.
• Offers a systemic solution for stubborn infections.
• Helps clear fungal infections from within.
• Reduces recurrence of fungal conditions.

Side Effects

• Headache
• Nausea
• Diarrhea
• Abdominal pain
• Dyspepsia
• Rash
• Urticaria
• Taste disturbance (dysgeusia)
• Liver enzyme elevations
• Arthralgia (joint pain)
• Myalgia (muscle pain)
• Fatigue

Safety Measures

• Alcohol - Avoid or minimize alcohol consumption during treatment, as both alcohol and terbinafine can be hepatotoxic, increasing the risk of liver damage.
• Pregnancy - Not recommended during pregnancy unless the potential benefits justify the potential risks to the fetus. Consult a doctor.
• Breastfeeding - Terbinafine is excreted into breast milk. Breastfeeding is not recommended during treatment due to potential adverse effects on the infant.
• Liver - Contraindicated in patients with chronic or active liver disease. Liver function tests should be performed before and during treatment.
• Kidney - Use with caution in patients with renal impairment. Dose reduction may be necessary in severe cases (creatinine clearance <50 mL/min).
• Lung - No specific contraindications related to lung conditions; generally considered safe for respiratory health.

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