Thaldo 100mg Capsule

About

Thalidomide is an immunomodulatory drug with anti-inflammatory and anti-angiogenic properties, primarily utilized in the treatment of multiple myeloma and erythema nodosum leprosum (ENL). Its mechanism of action involves modulating the immune system, inhibiting tumor necrosis factor-alpha (TNF-α), and interfering with angiogenesis, which is crucial for tumor growth. In multiple myeloma, it works by inhibiting the proliferation of myeloma cells and inducing apoptosis. For ENL, it helps to suppress the inflammatory response. Due to its potent teratogenic effects, strict risk management programs are in place to prevent fetal exposure. Patients must adhere to specific safety protocols, including contraception, throughout treatment.

Uses

• Treatment of multiple myeloma in combination with dexamethasone.
• Management of moderate to severe erythema nodosum leprosum (ENL).
• Used in certain refractory inflammatory conditions.
• Investigational use in some solid tumors.

Directions For Use

Take this capsule orally, usually once daily at bedtime, with a glass of water, as directed by your physician.

Benefits

• Effective in controlling multiple myeloma progression.
• Provides significant relief from symptoms of ENL.
• Modulates immune response to reduce inflammation.
• Inhibits the formation of new blood vessels in tumors.
• Can be used in combination therapy for enhanced efficacy.
• Oral administration offers convenience for patients.

Side Effects

• Drowsiness or sedation
• Peripheral neuropathy
• Constipation
• Skin rash
• Deep vein thrombosis (DVT)
• Dizziness
• Tremor
• Fatigue
• Low blood counts (leukopenia, thrombocytopenia)
• Dry skin
• Edema (swelling)
• Teratogenicity (severe birth defects)

Safety Measures

• Alcohol - Avoid or limit alcohol consumption due to increased risk of drowsiness and central nervous system depression.
• Pregnancy - Absolutely contraindicated in pregnancy due to severe teratogenicity. Strict contraception and pregnancy prevention programs are mandatory for all patients.
• Breastfeeding - Not recommended during breastfeeding as the drug may pass into breast milk and cause serious adverse effects in the infant.
• Liver - Use with caution in patients with liver impairment. Close monitoring of liver function tests is advised, and dose adjustments may be necessary.
• Kidney - Use with caution in patients with kidney impairment. Dose adjustments may be required, especially in severe renal dysfunction.
• Lung - Monitor for pulmonary events such as deep vein thrombosis or pulmonary embolism, particularly in patients with pre-existing risk factors.

Disclaimer

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