Trental 400

About

Trental 400 (pentoxifylline) is a hemorheologic agent primarily used to improve blood flow in patients suffering from peripheral arterial disease (PAD), particularly to alleviate symptoms like intermittent claudication. It works by decreasing blood viscosity and enhancing the flexibility of red blood cells, which allows them to pass more easily through narrow blood vessels. This action improves microcirculatory perfusion, leading to better oxygen delivery to tissues in the affected limbs.

The mechanism of action involves inhibiting phosphodiesterase, which results in increased levels of cyclic AMP within red blood cells and other cells. This contributes to its rheological effects, reducing blood stasis and improving overall circulation. Trental 400 also exhibits mild anti-inflammatory properties and can reduce platelet aggregation, further supporting its role in managing chronic occlusive arterial disease. The sustained-release formulation ensures a prolonged therapeutic effect, making it suitable for long-term management of PAD symptoms and improving patients' quality of life by increasing their walking distance and reducing pain.

Uses

• Treatment of intermittent claudication associated with PAD.
• Improvement of blood flow in chronic occlusive arterial disease.
• Reduction of pain and cramping in legs during exercise.
• Enhancement of microcirculation in peripheral vascular disorders.

Directions For Use

Take orally, usually with meals to minimize gastrointestinal upset. Follow your doctor's prescribed dosage and schedule strictly.

Benefits

• Reduces leg pain and cramping during walking.
• Increases walking distance in patients with PAD.
• Enhances blood flow to affected limbs.
• Decreases blood viscosity.
• Improves red blood cell flexibility.
• Helps improve tissue oxygenation.

Side Effects

• Nausea
• Vomiting
• Diarrhea
• Dizziness
• Headache
• Abdominal discomfort
• Indigestion
• Flushing
• Tremor
• Blurred vision
• Angina (chest pain)
• Arrhythmia (irregular heartbeat)

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may increase the risk of dizziness or gastrointestinal upset when taken with Trental 400.
• Pregnancy - Trental 400 should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult a doctor.
• Breastfeeding - Pentoxifylline is excreted in breast milk. Use with caution and only if clearly needed, under medical supervision.
• Liver - Use with caution in patients with severe hepatic impairment, as dose adjustment may be necessary due to altered metabolism.
• Kidney - Dose reduction may be required in patients with severe renal impairment (creatinine clearance < 30 mL/min) to prevent accumulation.
• Lung - Generally safe for use in patients with lung conditions, but always inform your doctor about all existing medical conditions.

Disclaimer

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