Versavo 400mg Injection

About

Versavo 400mg Injection is a biological medication, likely a biosimilar to bevacizumab, a recombinant humanized monoclonal antibody that targets and binds to vascular endothelial growth factor (VEGF). VEGF is a key signaling protein that stimulates angiogenesis, the formation of new blood vessels, which is crucial for tumor growth and metastasis. By inhibiting VEGF, bevacizumab prevents the formation of new blood vessels that supply tumors, thereby starving them of nutrients and oxygen, and inhibiting their growth. It is used in combination with various chemotherapy regimens to treat several types of advanced or metastatic cancers.

This anti-angiogenic therapy plays a vital role in oncology by disrupting the tumor's blood supply, which can lead to tumor shrinkage or stabilization of disease progression. Its efficacy has been established across a range of solid tumors, making it a cornerstone in the treatment of metastatic colorectal cancer, non-small cell lung cancer, renal cell carcinoma, and glioblastoma. Careful monitoring for potential side effects, particularly hypertension and bleeding, is essential during treatment.

Uses

• Treatment of metastatic colorectal cancer.
• Treatment of non-small cell lung cancer.
• Treatment of metastatic renal cell carcinoma.
• Treatment of recurrent glioblastoma.

Directions For Use

Administered intravenously by a healthcare professional, typically every 2-3 weeks, as part of a chemotherapy regimen.

Benefits

• Inhibits tumor angiogenesis.
• Slows tumor growth and progression.
• Improves progression-free survival.
• Used in combination with chemotherapy.
• Effective against various solid tumors.
• May reduce tumor size.

Side Effects

• Hypertension (high blood pressure).
• Proteinuria (protein in urine).
• Hemorrhage (bleeding events).
• Arterial thromboembolic events (e.g., stroke, MI).
• Venous thromboembolic events (e.g., DVT, PE).
• Gastrointestinal perforation.
• Wound healing complications.
• Fatigue.
• Headache.
• Diarrhea.
• Neutropenia.
• Infusion-related reactions.

Safety Measures

• Alcohol - No specific contraindication, but avoid excessive alcohol due to potential for general health decline during cancer treatment.
• Pregnancy - Contraindicated in pregnancy due to potential for fetal harm and teratogenicity; effective contraception is required.
• Breastfeeding - Not recommended during breastfeeding as it may be excreted in breast milk and cause adverse effects in the infant.
• Liver - Use with caution in patients with severe hepatic impairment; monitor liver function closely.
• Kidney - Use with caution in patients with renal impairment; monitor for proteinuria and kidney function.
• Lung - Use with caution in patients with a history of hemoptysis or pulmonary hemorrhage; monitor for respiratory symptoms.

Disclaimer

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