About
Telmisartan/Hydrochlorothiazide is a combination medication used to treat essential hypertension. Telmisartan is an angiotensin II receptor blocker (ARB) that selectively blocks the binding of angiotensin II to the AT1 receptor, leading to vasodilation and reduced aldosterone secretion, thereby lowering blood pressure. Hydrochlorothiazide is a thiazide diuretic that increases the excretion of sodium and water by inhibiting sodium reabsorption in the distal convoluted tubule, which further contributes to blood pressure reduction. The combination provides additive antihypertensive effects, often achieving better blood pressure control than either agent alone, especially in patients who do not respond adequately to monotherapy. This dual mechanism of action targets different pathways involved in blood pressure regulation, offering a comprehensive approach to managing hypertension and reducing the risk of associated cardiovascular complications.
Uses
- Treatment of essential hypertension.
- Blood pressure control in patients not adequately controlled by monotherapy.
- Reduction of cardiovascular risk in high-risk patients.
- Management of fluid retention associated with hypertension.
Directions For Use
Take one tablet orally once daily, preferably at the same time each day, with or without food, as directed by your physician.
Benefits
- Provides effective and sustained blood pressure reduction.
- Combines two different mechanisms for enhanced antihypertensive effect.
- Reduces the risk of stroke and heart attack.
- Offers convenient once-daily dosing.
- Helps manage fluid balance in hypertensive patients.
- May improve patient compliance due to combination therapy.
Side Effects
- Dizziness
- Fatigue
- Headache
- Nausea
- Diarrhea
- Upper respiratory tract infection
- Back pain
- Muscle cramps
- Hypotension
- Hyperkalemia (less common with HCTZ)
- Hypokalemia (due to HCTZ)
- Increased uric acid levels
Safety Measures
- Alcohol - Alcohol may increase the hypotensive effect of this medication, leading to dizziness or lightheadedness. Avoid excessive alcohol consumption.
- Pregnancy - Contraindicated during the second and third trimesters of pregnancy due to potential fetal harm. Use should be avoided.
- Breastfeeding - Both telmisartan and hydrochlorothiazide are excreted in breast milk. Breastfeeding is not recommended while taking this medication.
- Liver - Use with caution in patients with severe hepatic impairment, as it may exacerbate fluid and electrolyte imbalances.
- Kidney - Contraindicated in patients with anuria or severe renal impairment. Dosage adjustment may be needed for moderate impairment.
- Lung - Generally safe for use in patients with lung conditions, though caution is advised in patients with a history of allergy or asthma due due to sulfonamide component (HCTZ).
Disclaimer
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