TELMA AZ 80 10S

About

TELMA AZ 80 is a combination medication used for the treatment of essential hypertension, typically combining an angiotensin II receptor blocker (ARB) like Telmisartan 80mg with a dihydropyridine calcium channel blocker (CCB) like Azelnidipine. Telmisartan works by blocking the AT1 receptors, leading to vasodilation and reduced blood pressure. Azelnidipine, on the other hand, blocks L-type and N-type calcium channels, causing relaxation of vascular smooth muscle and further lowering blood pressure. This dual mechanism of action provides comprehensive and synergistic blood pressure control.

The combination is particularly effective for patients whose blood pressure is not adequately controlled by monotherapy with either an ARB or a CCB. It offers the benefits of both classes, including sustained blood pressure reduction, cardiovascular protection, and a potentially reduced incidence of side effects compared to higher doses of individual agents. Regular monitoring of blood pressure, kidney function, and electrolytes is important to ensure optimal therapeutic outcomes and patient safety.

Uses

• Treatment of essential hypertension.
• Management of resistant hypertension.
• Prevention of cardiovascular events.
• Adjunctive therapy for high-risk hypertensive patients.

Directions For Use

Take one tablet orally once daily, preferably at the same time each day, with or without food, as directed by your physician. Do not crush or chew the tablet.

Benefits

• Potent and sustained blood pressure reduction.
• Dual mechanism of action for comprehensive control.
• Reduces risk of cardiovascular morbidity and mortality.
• May mitigate CCB-induced peripheral edema.
• Convenient once-daily dosing.
• Well-tolerated in many patients.

Side Effects

• Dizziness.
• Headache.
• Peripheral edema (swelling of ankles/feet).
• Fatigue.
• Hypotension.
• Nausea.
• Diarrhea.
• Hyperkalemia.
• Palpitations.
• Flushing.
• Back pain.
• Upper respiratory tract infection.

Safety Measures

• Alcohol - Alcohol can enhance the blood pressure-lowering effect and increase the risk of dizziness; use with caution.
• Pregnancy - Contraindicated during the second and third trimesters due to risk of fetal injury from the ARB component.
• Breastfeeding - Not recommended during breastfeeding; consider alternative treatments or discontinue breastfeeding.
• Liver - Use with caution in patients with hepatic impairment; dose adjustment may be necessary.
• Kidney - Monitor renal function closely, especially in patients with pre-existing renal impairment or renal artery stenosis.
• Lung - Generally safe for patients with lung conditions as it does not directly affect respiratory function.

Disclaimer

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