Abraace 100mg Injection

About

Abraace 100mg Injection likely contains a formulation of paclitaxel, such as paclitaxel protein-bound particles (nab-paclitaxel), an antineoplastic agent belonging to the taxane class. This medication works by interfering with the normal function of microtubules, which are essential for cell division. It promotes the assembly of tubulin into stable microtubules and inhibits their depolymerization, leading to the arrest of cells in the G2/M phase of the cell cycle. This disruption of the mitotic process ultimately induces apoptosis in rapidly dividing cancer cells, thereby inhibiting tumor growth and progression.

The protein-bound formulation allows for intravenous administration without the need for solvents like Cremophor EL, which are associated with hypersensitivity reactions. This often results in a more favorable safety profile regarding hypersensitivity and potentially allows for higher dosing. Abraace is used in the treatment of various solid tumors, either as a single agent or in combination with other chemotherapeutic drugs. Its efficacy in improving survival and response rates makes it a valuable option in oncology. Close monitoring for side effects, particularly myelosuppression and neuropathy, is crucial.

Uses

• Metastatic breast cancer
• Non-small cell lung cancer (NSCLC)
• Metastatic pancreatic adenocarcinoma
• Advanced gastric cancer

Directions For Use

Administered intravenously by a healthcare professional. Dosage and infusion rate are determined by the physician based on the specific cancer type and patient's condition.

Benefits

• Effective against various solid tumors.
• Reduced risk of hypersensitivity reactions.
• Does not require premedication with corticosteroids.
• Can improve progression-free and overall survival.
• Often used in combination therapies.
• Contributes to tumor size reduction.

Side Effects

• Myelosuppression (neutropenia, anemia, thrombocytopenia)
• Peripheral neuropathy
• Alopecia (hair loss)
• Nausea and vomiting
• Fatigue
• Diarrhea
• Arthralgia/myalgia (joint/muscle pain)
• Mucositis
• Liver enzyme elevation
• Edema
• Infection
• Hypersensitivity reactions (less common than solvent-based paclitaxel)

Safety Measures

• Alcohol - Avoid alcohol consumption as it may exacerbate liver toxicity and other side effects associated with this medication.
• Pregnancy - Contraindicated in pregnancy due to potential fetal harm. Effective contraception is required for both male and female patients during treatment and for a period thereafter.
• Breastfeeding - Breastfeeding is not recommended during treatment and for a specified period after the last dose due to the potential for serious adverse reactions in the infant.
• Liver - Use with caution in patients with hepatic impairment; dose adjustments may be necessary. Close monitoring of liver function tests is crucial.
• Kidney - Use with caution in patients with renal impairment. While not primarily renally cleared, kidney function should be monitored.
• Lung - Monitor for signs of interstitial lung disease or pneumonitis, especially in patients with pre-existing lung conditions.

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