Adplatin 100mg Injection

About

Cisplatin is a potent platinum-based chemotherapy agent that exerts its cytotoxic effects primarily by forming DNA adducts. These adducts lead to intra-strand and inter-strand cross-links in DNA, which interfere with DNA replication and transcription, ultimately triggering apoptosis in cancer cells. Its mechanism involves the binding of platinum to guanine bases, causing structural distortions that are recognized by cellular repair mechanisms, but ultimately overwhelm them in rapidly dividing cells. Cisplatin is a cornerstone in the treatment of various solid tumors and is administered intravenously, often requiring extensive pre-hydration and antiemetic prophylaxis due to its significant nephrotoxic and emetogenic potential. Its efficacy, particularly in combination regimens, has made it indispensable in modern oncology, despite its challenging side effect profile which necessitates careful patient management and monitoring.

Uses

• Testicular cancer
• Ovarian cancer
• Bladder cancer
• Head and neck cancer

Directions For Use

Administered intravenously, typically over several hours, by a qualified healthcare professional. Pre-hydration and antiemetics are often required.

Benefits

• Highly effective against a range of solid tumors.
• Often curative in certain cancers like testicular cancer.
• Synergistic with radiation therapy and other chemotherapies.
• Well-established efficacy in combination regimens.
• Can achieve significant tumor response.
• Contributes to improved survival outcomes.

Side Effects

• Severe nausea and vomiting (highly emetogenic)
• Nephrotoxicity (kidney damage, dose-limiting)
• Ototoxicity (hearing loss, tinnitus)
• Myelosuppression (less severe than some other agents)
• Peripheral neuropathy
• Electrolyte disturbances (hypomagnesemia, hypokalemia)
• Anaphylactic-like reactions
• Fatigue
• Alopecia (less common)
• Mucositis
• Injection site reactions
• Elevated liver enzymes

Safety Measures

• Alcohol - Avoid or limit alcohol due to potential for increased gastrointestinal irritation and liver strain.
• Pregnancy - Contraindicated. May cause severe fetal harm. Effective contraception is essential during and after treatment.
• Breastfeeding - Not recommended. The drug can be excreted in breast milk and pose a risk to the infant.
• Liver - Use with caution; monitor liver function, though primarily renally excreted.
• Kidney - Contraindicated in severe renal impairment. Requires careful monitoring of renal function and aggressive hydration to prevent nephrotoxicity.
• Lung - Use with caution in patients with pre-existing lung conditions, though direct pulmonary toxicity is rare.

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