About
This combination therapy integrates Amlodipine, a dihydropyridine calcium channel blocker, with Losartan Potassium, an angiotensin II receptor blocker (ARB), to provide comprehensive management of hypertension. Amlodipine exerts its antihypertensive effect by relaxing vascular smooth muscle, leading to peripheral vasodilation and a reduction in blood pressure. Losartan, on the other hand, specifically blocks the binding of angiotensin II to its receptors, preventing vasoconstriction and aldosterone secretion, which further contributes to blood pressure reduction.
The synergistic action of these two agents offers superior blood pressure control compared to monotherapy, particularly in patients whose hypertension is not adequately managed by a single agent. This combination not only effectively lowers blood pressure but also provides significant organ protection, especially for the kidneys and heart, thereby reducing the overall risk of cardiovascular and renal complications associated with chronic hypertension.
Uses
- Essential hypertension
- Hypertension not controlled by monotherapy
- Reduction of cardiovascular risk
- Protection against target organ damage
Directions For Use
Take one tablet orally once daily, with or without food, as prescribed by your doctor.
Benefits
- Provides dual mechanism for blood pressure control.
- Effectively lowers high blood pressure.
- Reduces risk of stroke and heart attack.
- Offers kidney protection in hypertensive patients.
- Improves vascular relaxation.
- Well-tolerated for long-term use.
Side Effects
- Dizziness
- Headache
- Fatigue
- Edema (swelling of ankles/feet)
- Flushing
- Nausea
- Abdominal pain
- Palpitations
- Cough (less common than ACE inhibitors)
- Hyperkalemia (elevated potassium)
- Hypotension (low blood pressure)
- Muscle cramps
Safety Measures
- Alcohol - Alcohol can increase the blood pressure-lowering effect and worsen dizziness. Use with caution.
- Pregnancy - Contraindicated during the second and third trimesters of pregnancy due to potential fetal harm.
- Breastfeeding - Not recommended during breastfeeding as both components may pass into breast milk.
- Liver - Use with caution in patients with liver impairment; dose adjustment may be necessary.
- Kidney - Use with caution in patients with renal artery stenosis or severe renal impairment; monitor kidney function.
- Lung - Generally safe for use in patients with lung conditions; no specific precautions.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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| Shop Location | Assam, India |
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