LOSAR-A TAB 10S

About

Losartan/Amlodipine is a combination medication that combines an angiotensin II receptor blocker (ARB) with a dihydropyridine calcium channel blocker, offering a dual mechanism for managing hypertension. Losartan works by blocking the effects of angiotensin II, leading to vasodilation and reduced fluid retention. Amlodipine, on the other hand, relaxes blood vessels by blocking calcium entry into vascular smooth muscle cells, resulting in peripheral vasodilation and a reduction in blood pressure.

This synergistic action provides more comprehensive blood pressure control than either agent alone, making it particularly effective for patients whose blood pressure is not adequately controlled by monotherapy. The combination helps to reduce the risk of cardiovascular events associated with high blood pressure. It is typically prescribed as a once-daily oral medication, providing sustained antihypertensive effects throughout the day.

Uses

• Treatment of essential hypertension.
• For patients whose blood pressure is not adequately controlled by monotherapy.
• To reduce the risk of cardiovascular events.
• As an adjunct to other antihypertensive therapies.

Directions For Use

Take orally, usually once daily, with or without food, as prescribed by your doctor.

Swallow the tablet whole; do not crush, chew, or break it.

Benefits

• Enhanced and sustained blood pressure control.
• Dual mechanism of action for comprehensive management.
• Reduces risk of cardiovascular events.
• Convenient once-daily dosing.
• May improve patient adherence.
• Effective for resistant hypertension.

Side Effects

• Dizziness
• Fatigue
• Peripheral edema (swelling of ankles/feet)
• Headache
• Flushing
• Hypotension (low blood pressure)
• Hyperkalemia (high potassium levels, due to Losartan)
• Renal dysfunction (worsening kidney function)
• Nausea
• Abdominal pain
• Palpitations
• Angioedema (rare, swelling of face/throat)

Safety Measures

• Alcohol - Alcohol can further lower blood pressure, increasing the risk of dizziness or fainting. Use with caution and discuss with your doctor.
• Pregnancy - Contraindicated during the second and third trimesters due to risk of fetal injury and death from Losartan. Avoid use during pregnancy.
• Breastfeeding - Not recommended during breastfeeding as Losartan may pass into breast milk and potentially harm the infant. Consult your doctor.
• Liver - Use with caution in patients with hepatic impairment, as dosage adjustments may be necessary for both components.
• Kidney - Use with caution in patients with renal impairment; monitor kidney function closely, especially in those with severe impairment or renal artery stenosis.
• Lung - Generally safe for patients with lung conditions. Unlike ACE inhibitors, Losartan rarely causes cough.

Disclaimer

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