About
This medication combines an angiotensin II receptor blocker (ARB), such as Valsartan, with Hydrochlorothiazide, a thiazide diuretic, to provide comprehensive treatment for essential hypertension. The ARB component works by selectively blocking the action of angiotensin II, a potent natural substance that narrows blood vessels. This blockade leads to the relaxation of blood vessels, reducing blood pressure and easing the heart's workload. Hydrochlorothiazide complements this action by increasing the excretion of sodium and water from the body through the kidneys, which further reduces blood volume and blood pressure. This dual therapy is particularly effective for patients who require more than one agent to achieve their blood pressure goals or who have experienced inadequate control with monotherapy. The synergistic effect of these two agents ensures robust blood pressure reduction and helps to mitigate the long-term risks of cardiovascular complications.
Uses
- Treatment of essential hypertension.
- Management of high blood pressure when monotherapy is insufficient.
- Reduction of fluid retention.
- Prevention of cardiovascular events.
Directions For Use
Take this medication orally once daily, with or without food, as directed by your physician.
Benefits
- Effective blood pressure reduction.
- Dual action for enhanced control.
- Reduces excess fluid and salt.
- Lowers risk of heart attack and stroke.
- Provides sustained blood pressure lowering.
- Convenient once-daily dosing.
Side Effects
- Dizziness
- Headache
- Fatigue
- Nausea
- Hypotension
- Electrolyte imbalance (e.g., hypokalemia)
- Increased urination
- Muscle cramps
- Cough (less common than ACE inhibitors)
- Back pain
- Photosensitivity
Safety Measures
- Alcohol - Avoid or limit alcohol intake as it can exacerbate blood pressure lowering and increase dizziness.
- Pregnancy - Contraindicated during pregnancy, especially in the second and third trimesters, due to fetal toxicity.
- Breastfeeding - Not recommended; components may be excreted in breast milk and could harm the infant.
- Liver - Use with caution in patients with liver impairment; dose adjustment may be necessary.
- Kidney - Contraindicated in anuria and severe renal impairment; careful monitoring of kidney function is essential.
- Lung - Generally safe, but caution with a history of asthma or allergies to sulfonamide-derived drugs due to hydrochlorothiazide.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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