LOSAR H 10S

About

Losartan/Hydrochlorothiazide is a combination medication that pairs an angiotensin II receptor blocker (ARB) with a thiazide diuretic, providing a powerful approach to managing hypertension. Losartan works by blocking the effects of angiotensin II, leading to vasodilation and reduced aldosterone secretion. Hydrochlorothiazide (HCTZ) is a diuretic that increases the excretion of sodium and water by the kidneys, thereby reducing blood volume and peripheral resistance.

The combination of these two agents offers additive antihypertensive effects, often achieving better blood pressure control than either drug used alone. This makes it particularly useful for patients who require more aggressive blood pressure reduction or those who experience fluid retention. The diuretic component also helps to counteract the potential for fluid retention that can sometimes occur with ARBs. It is typically prescribed as a once-daily oral medication for sustained blood pressure management.

Uses

• Treatment of essential hypertension.
• For patients whose blood pressure is not adequately controlled by monotherapy.
• To reduce fluid retention associated with hypertension.
• As an adjunct to other antihypertensive therapies.

Directions For Use

Take orally, usually once daily, with or without food, as prescribed by your doctor.

Swallow the tablet whole; do not crush, chew, or break it.

Benefits

• Enhanced and sustained blood pressure control.
• Dual mechanism of action for comprehensive management.
• Reduces fluid retention and swelling.
• Convenient once-daily dosing.
• May improve patient adherence.
• Effective for resistant hypertension.

Side Effects

• Dizziness
• Fatigue
• Hypotension (low blood pressure)
• Hyperkalemia (due to Losartan)
• Hypokalemia (due to HCTZ)
• Renal dysfunction (worsening kidney function)
• Dehydration
• Nausea
• Muscle cramps
• Increased urination
• Photosensitivity
• Gout (due to HCTZ)

Safety Measures

• Alcohol - Alcohol can further lower blood pressure and increase the risk of dizziness or fainting. Use with caution and discuss with your doctor.
• Pregnancy - Contraindicated during the second and third trimesters due to risk of fetal injury and death from Losartan. Avoid use during pregnancy.
• Breastfeeding - Not recommended during breastfeeding as Losartan and HCTZ may pass into breast milk and potentially harm the infant. Consult your doctor.
• Liver - Use with caution in patients with hepatic impairment, as HCTZ can precipitate hepatic encephalopathy. Monitor closely.
• Kidney - Contraindicated in anuria. Use with extreme caution in patients with severe renal impairment; monitor kidney function and electrolytes closely.
• Lung - Generally safe for patients with lung conditions. However, HCTZ can rarely cause pulmonary edema in susceptible individuals.

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