Anamit Tablet

About

Anastrozole is a potent and selective non-steroidal aromatase inhibitor, primarily used in the treatment of hormone receptor-positive breast cancer in postmenopausal women. Its mechanism of action involves blocking the enzyme aromatase, which is crucial for the conversion of androgens into estrogens in peripheral tissues. In postmenopausal women, this peripheral aromatization is the main source of estrogen production. By effectively inhibiting aromatase, anastrozole significantly reduces circulating estrogen levels. This reduction starves hormone receptor-positive breast cancer cells of the estrogen they require for growth and proliferation, thereby slowing disease progression or preventing recurrence. It is a cornerstone therapy in endocrine treatment strategies, offering a targeted approach to managing estrogen-dependent tumors and improving patient outcomes. Clinical studies have demonstrated its efficacy in both adjuvant and metastatic settings, often showing superior outcomes compared to older endocrine therapies like tamoxifen in specific patient populations.

Uses

• Adjuvant treatment of hormone receptor-positive early breast cancer in postmenopausal women.
• First-line treatment of hormone receptor-positive or hormone receptor-unknown advanced breast cancer in postmenopausal women.
• Treatment of advanced breast cancer in postmenopausal women with disease progression following tamoxifen therapy.
• Off-label use in some cases of gynecomastia or infertility.

Directions For Use

Take this medicine orally, usually once daily, with or without food, as directed by your doctor. Swallow the tablet whole with a glass of water.

Benefits

• Effectively lowers estrogen levels in postmenopausal women.
• Reduces the risk of breast cancer recurrence.
• Slows the progression of advanced breast cancer.
• Oral administration offers convenience.
• May be used as a first-line or second-line therapy.
• Generally well-tolerated compared to chemotherapy.

Side Effects

• Hot flashes
• Joint pain (arthralgia)
• Nausea
• Fatigue
• Headache
• Bone thinning (osteoporosis)
• Vaginal dryness
• Hair thinning
• Rash
• High blood pressure
• Swelling in ankles/feet
• Mood changes

Safety Measures

• Alcohol - Moderate alcohol consumption is generally not contraindicated, but excessive intake may exacerbate liver-related side effects or general fatigue.
• Pregnancy - Anastrozole is contraindicated in pregnant women due to potential harm to the fetus; effective contraception is required for premenopausal women.
• Breastfeeding - It is not recommended during breastfeeding as it may pass into breast milk and could harm the infant or suppress milk production.
• Liver - Use with caution in patients with moderate to severe liver impairment; dose adjustment may be necessary.
• Kidney - No dose adjustment is typically required for mild to moderate renal impairment; use with caution in severe renal impairment.
• Lung - Generally no specific precautions for lung conditions, but monitor for any new or worsening respiratory symptoms.

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