Apragem 1gm RTU Injection

About

Apragem 1gm RTU Injection contains gemcitabine, a nucleoside analog antimetabolite used in various cancer treatments. Gemcitabine acts by inhibiting DNA synthesis and repair, leading to cell death. Once inside the cell, gemcitabine is phosphorylated to its active diphosphate and triphosphate forms. Gemcitabine diphosphate inhibits ribonucleotide reductase, reducing the deoxycytidine triphosphate pool necessary for DNA synthesis. Gemcitabine triphosphate is incorporated into DNA, causing chain termination and inhibiting DNA polymerase. This dual mechanism makes it effective against rapidly dividing cancer cells. It is administered intravenously and is a cornerstone in the treatment of several solid tumors.

Uses

• Treatment of non-small cell lung cancer.
• Treatment of pancreatic cancer.
• Treatment of breast cancer.
• Treatment of ovarian cancer.

Directions For Use

Administered intravenously by a healthcare professional.
Dosage and infusion rate are determined by your doctor based on your condition.

Benefits

• Effective against various solid tumors.
• Can improve survival rates in certain cancers.
• Often used in combination chemotherapy regimens.
• May reduce tumor size and progression.
• Available as a ready-to-use formulation.
• Well-established efficacy in oncology.

Side Effects

• Myelosuppression (anemia, leukopenia, thrombocytopenia)
• Nausea and vomiting
• Fatigue
• Fever
• Rash
• Hair loss (alopecia)
• Diarrhea
• Constipation
• Flu-like symptoms
• Edema
• Elevated liver enzymes
• Proteinuria

Safety Measures

• Alcohol - Alcohol should be avoided during treatment as it can worsen liver toxicity and other side effects.
• Pregnancy - Gemcitabine is teratogenic and embryotoxic. It is contraindicated in pregnancy; effective contraception is required.
• Breastfeeding - Breastfeeding is contraindicated during gemcitabine treatment due to potential harm to the infant.
• Liver - Use with caution in patients with pre-existing liver impairment; monitor liver function closely.
• Kidney - Use with caution in patients with renal impairment; dose adjustments may be necessary.
• Lung - Rare but serious pulmonary toxicity can occur; monitor for symptoms like dyspnea or cough.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.