GEMTAZ 1 GM INJ 1vial

About

Gemtaz (Gemcitabine) is an antimetabolite chemotherapy agent widely used in the treatment of various solid tumors, including pancreatic, non-small cell lung, breast, and ovarian cancers. It is a nucleoside analog that, once intracellularly phosphorylated, inhibits DNA synthesis and repair by incorporating into DNA and RNA, leading to chain termination and ultimately inducing cell death. Gemcitabine's mechanism of action also involves inhibiting ribonucleotide reductase, an enzyme essential for DNA synthesis. Administered intravenously, it is often used alone or in combination with other chemotherapeutic agents or radiation therapy to improve treatment outcomes, reduce tumor burden, and provide palliative symptom relief for patients with advanced malignancies.

Uses

• Pancreatic cancer.
• Non-small cell lung cancer.
• Metastatic breast cancer.
• Ovarian cancer.

Directions For Use

Administered intravenously by a qualified healthcare professional in a clinical setting.

Benefits

• Broad spectrum anti-tumor activity.
• Often used effectively in combination therapies.
• Improves survival in certain advanced cancers.
• Relatively well-tolerated compared to some other chemotherapies.
• Provides palliative symptom relief in advanced disease.
• Reduces tumor size and disease progression.

Side Effects

• Myelosuppression (neutropenia, thrombocytopenia, anemia)
• Nausea
• Vomiting
• Fatigue
• Flu-like symptoms
• Rash
• Alopecia (hair thinning)
• Elevated liver enzymes
• Proteinuria
• Dyspnea (shortness of breath)
• Peripheral edema
• Stomatitis

Safety Measures

• Alcohol - Avoid or limit alcohol due to potential for increased liver toxicity and gastrointestinal upset.
• Pregnancy - Contraindicated; causes fetal harm. Women of childbearing potential must use effective contraception.
• Breastfeeding - Contraindicated; potential for serious adverse effects in the infant. Discontinue breastfeeding.
• Liver - Use with caution; dose adjustment may be needed in patients with hepatic impairment.
• Kidney - Use with caution; dose adjustment may be needed in patients with renal impairment.
• Lung - Can cause severe pulmonary toxicity, including interstitial pneumonitis and ARDS; monitor closely for respiratory symptoms.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.