ARNEY 100 TAB 14S

About

ARNEY 100 TAB typically contains Sacubitril and Valsartan, a combination medication known as an Angiotensin Receptor Neprilysin Inhibitor (ARNI). This innovative drug class is primarily used in the management of chronic heart failure with reduced ejection fraction. Valsartan, an angiotensin receptor blocker (ARB), works by blocking the effects of angiotensin II, a potent vasoconstrictor, leading to vasodilation and reduced blood pressure, and decreasing the workload on the heart.

Sacubitril is a neprilysin inhibitor that prevents the breakdown of natriuretic peptides, which are natural hormones that promote vasodilation, natriuresis (sodium excretion), and diuresis (water excretion). By enhancing the levels of these beneficial peptides, Sacubitril counteracts the neurohormonal overactivation seen in heart failure. The synergistic action of Sacubitril and Valsartan provides a dual mechanism to improve cardiac function, reduce symptoms, and significantly lower the risk of cardiovascular death and heart failure hospitalizations in eligible patients, representing a major advancement in heart failure therapy.

Uses

• Treatment of chronic heart failure with reduced ejection fraction
• Reduction of cardiovascular death and heart failure hospitalization
• Management of symptomatic heart failure
• Improvement of physical capacity in heart failure patients

Directions For Use

Take one tablet twice daily, as directed by your physician. It can be taken with or without food.

Benefits

• Significantly reduces heart failure hospitalizations
• Improves survival rates in heart failure patients
• Enhances cardiac function and reduces cardiac remodeling
• Alleviates symptoms like shortness of breath and fatigue
• Improves overall quality of life for heart failure patients
• Lowers blood pressure effectively

Side Effects

• Hypotension (low blood pressure)
• Hyperkalemia (high potassium levels)
• Cough
• Dizziness
• Renal impairment
• Fatigue
• Nausea
• Diarrhea
• Syncope (fainting)
• Angioedema (swelling of face, lips, tongue)
• Headache
• Anemia

Safety Measures

• Alcohol - Use with caution; alcohol may exacerbate hypotension and dizziness.
• Pregnancy - Contraindicated during pregnancy as it can cause fetal injury or death.
• Breastfeeding - Not recommended during breastfeeding due to potential adverse effects on the infant.
• Liver - Use with caution in patients with mild to moderate liver impairment; not studied in severe impairment.
• Kidney - Monitor renal function closely; dose adjustment may be needed in severe kidney impairment.
• Lung - Generally safe for lung conditions; however, cough is a common side effect.

Disclaimer

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