About
Sacuval 50 contains Sacubitril and Valsartan, an angiotensin receptor-neprilysin inhibitor (ARNI) combination indicated for the treatment of chronic heart failure with reduced ejection fraction (HFrEF). Sacubitril inhibits neprilysin, an enzyme responsible for the degradation of natriuretic peptides, leading to increased levels of these peptides which promote vasodilation and natriuresis. Valsartan is an angiotensin II receptor blocker (ARB) that inhibits the harmful effects of angiotensin II, such as vasoconstriction and aldosterone release. By combining these two mechanisms, Sacuval provides a dual therapeutic approach that significantly reduces the risk of cardiovascular death and heart failure hospitalization in patients with HFrEF, offering a substantial improvement over traditional therapies.
Uses
- Treatment of chronic heart failure with reduced ejection fraction (HFrEF).
- To reduce the risk of cardiovascular death.
- To reduce the risk of heart failure hospitalization.
- As a replacement for an ACE inhibitor or other ARB in eligible patients.
Directions For Use
Take this medication orally, usually twice daily, with or without food, as directed by your doctor. Swallow the tablet whole with water.
Benefits
- Significantly reduces cardiovascular death.
- Reduces heart failure hospitalizations.
- Improves symptoms and quality of life in HFrEF.
- Dual mechanism of action for comprehensive benefit.
- Superior to ACE inhibitors in certain heart failure outcomes.
- Well-established efficacy in clinical trials.
Side Effects
- Hypotension
- Hyperkalemia
- Renal impairment
- Cough
- Dizziness
- Fatigue
- Nausea
- Diarrhea
- Back pain
- Angioedema (rare but serious)
- Anemia
- Hypoglycemia
Safety Measures
- Alcohol - Avoid excessive alcohol consumption as it may increase the risk of low blood pressure and dizziness when taken with this medication.
- Pregnancy - Contraindicated during pregnancy, especially in the second and third trimesters, due to potential fetal harm and death.
- Breastfeeding - Not recommended during breastfeeding as it may pass into breast milk and harm the infant. Consult a doctor.
- Liver - Use with caution in patients with moderate hepatic impairment; not recommended in severe hepatic impairment.
- Kidney - Use with caution in patients with renal impairment; monitor kidney function and potassium levels closely.
- Lung - Generally safe for use in patients with lung conditions; however, angioedema can affect the airway and requires immediate medical attention.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
Our goal is to complement, not replace, the essential doctor-patient relationship.
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| Shop Location | Assam, India |
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