About
Sacubitril/Valsartan, marketed as Entresto, is an angiotensin receptor-neprilysin inhibitor (ARNI) specifically indicated for the treatment of chronic heart failure with reduced ejection fraction (HFrEF). This innovative medication combines sacubitril, a neprilysin inhibitor, with valsartan, an angiotensin II receptor blocker. Sacubitril enhances the levels of endogenous natriuretic peptides by inhibiting neprilysin, leading to beneficial effects such as vasodilation, natriuresis, and diuresis, which counteract the neurohormonal overactivation seen in heart failure. Valsartan simultaneously blocks the detrimental effects of angiotensin II. This dual mechanism provides significant cardiovascular benefits, including a reduction in the risk of cardiovascular death and heart failure hospitalizations, by improving cardiac function, reducing cardiac remodeling, and alleviating symptoms in patients with HFrEF.
Uses
- Treatment of chronic heart failure with reduced ejection fraction (HFrEF).
- Reduction of cardiovascular death and heart failure hospitalization.
- Improvement of symptoms and physical limitations in HFrEF.
- Management of symptomatic chronic heart failure in adults.
Directions For Use
Take this medication orally, usually twice daily, with or without food, as directed by your healthcare provider.
Benefits
- Significantly reduces the risk of cardiovascular death and heart failure hospitalization.
- Improves symptoms and quality of life for heart failure patients.
- Offers a novel mechanism of action targeting multiple pathways.
- Provides superior efficacy compared to ACE inhibitors in HFrEF.
- Helps to reverse or slow cardiac remodeling.
- Generally well-tolerated with a manageable side effect profile.
Side Effects
- Hypotension (low blood pressure)
- Hyperkalemia (high potassium levels)
- Cough
- Dizziness
- Renal impairment
- Fatigue
- Nausea
- Diarrhea
- Angioedema (rare but serious)
- Headache
- Syncope
- Anemia
Safety Measures
- Alcohol - Alcohol can exacerbate the hypotensive effects of this medication, increasing the risk of dizziness or fainting. Use with caution.
- Pregnancy - Contraindicated during pregnancy due to the valsartan component, which can cause fetal harm or death. Discontinue immediately if pregnancy is detected.
- Breastfeeding - Not recommended during breastfeeding as it is unknown if sacubitril/valsartan passes into breast milk. A doctor should assess the risk-benefit.
- Liver - Use with caution in patients with moderate hepatic impairment. Not recommended in severe hepatic impairment.
- Kidney - Use with caution in patients with renal impairment. Monitor kidney function and potassium levels closely, especially in severe cases.
- Lung - Generally safe for use in patients with lung conditions. However, angioedema, though rare, can affect the airway and requires immediate medical attention.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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