ARNICOR 50 10S

About

Nicorandil is a unique anti-anginal agent distinguished by its dual mechanism of action, functioning as both a potassium channel opener and a nitrate-like compound. Its primary therapeutic effect stems from the activation of ATP-sensitive potassium channels within vascular smooth muscle cells, which induces hyperpolarization and subsequent relaxation, leading to significant vasodilation of both arterial and venous beds. Concurrently, nicorandil's nitrate-like properties facilitate the release of nitric oxide, further enhancing its vasodilatory effects. This combined action effectively reduces both cardiac preload and afterload, thereby decreasing myocardial oxygen demand and improving coronary blood flow to ischemic areas. Nicorandil is highly effective in the prevention and long-term treatment of stable angina pectoris, providing substantial symptomatic relief and enhancing exercise tolerance in patients suffering from chronic coronary artery disease.

Uses

• Prevention and long-term treatment of stable angina pectoris.
• Management of chronic stable angina.
• To reduce the frequency of angina attacks.
• Improvement of exercise tolerance in angina patients.

Directions For Use

Take orally as directed by your physician, usually two or three times daily.

Benefits

• Reduces the frequency and severity of angina attacks.
• Improves exercise tolerance.
• Acts as both an arterial and venous vasodilator.
• Decreases myocardial oxygen demand.
• Increases coronary blood flow.
• Offers a dual mechanism of action for angina relief.

Side Effects

• Headache (common, especially initially)
• Dizziness
• Flushing
• Nausea
• Vomiting
• Weakness
• Palpitations
• Hypotension (low blood pressure)
• Gastrointestinal ulcers (rare, but serious)
• Myalgia (muscle pain)
• Rash
• Fatigue

Safety Measures

• Alcohol - Alcohol may enhance the hypotensive effect; use with caution.
• Pregnancy - Not recommended during pregnancy; consult a doctor.
• Breastfeeding - Not recommended during breastfeeding; consult a doctor.
• Liver - Use with caution in patients with hepatic impairment; no specific dose adjustment usually required.
• Kidney - Use with caution in patients with renal impairment; no specific dose adjustment usually required.
• Lung - Generally safe for lung conditions, but monitor for any unexplained respiratory symptoms.

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