SACURISE 50MG 14S

About

SACURISE 50MG, containing sacubitril and valsartan, is an angiotensin receptor-neprilysin inhibitor (ARNI) indicated for the treatment of chronic heart failure with reduced ejection fraction (HFrEF). This medication combines a neprilysin inhibitor (sacubitril) with an angiotensin receptor blocker (valsartan) to provide a dual mechanism of action. Sacubitril works by inhibiting neprilysin, an enzyme responsible for the degradation of beneficial natriuretic peptides, thereby increasing their levels. This leads to vasodilation, natriuresis, and diuresis, which are favorable effects in heart failure. Valsartan, on the other hand, blocks the angiotensin II type 1 receptor, counteracting the harmful effects of angiotensin II, such as vasoconstriction, aldosterone secretion, and cardiac remodeling. The synergistic action of these two components helps to significantly reduce cardiovascular mortality and heart failure hospitalizations in eligible patients with HFrEF. The 50mg dose typically refers to the combined strength (e.g., 24mg sacubitril / 26mg valsartan).

Uses

• Treatment of chronic heart failure with reduced ejection fraction.
• Reduction of cardiovascular death and heart failure hospitalization.
• Improvement of symptoms and physical limitations in heart failure.
• Management of symptomatic chronic heart failure in adults.

Directions For Use

Take orally, usually twice daily, with or without food, as directed by your physician.

Benefits

• Reduces risk of cardiovascular death.
• Decreases heart failure hospitalizations.
• Improves cardiac function.
• Enhances quality of life for heart failure patients.
• Lowers blood pressure.
• Reduces fluid retention.

Side Effects

• Hypotension (low blood pressure)
• Hyperkalemia (high potassium levels)
• Renal impairment (kidney problems)
• Cough
• Dizziness
• Fatigue
• Nausea
• Diarrhea
• Angioedema (swelling under the skin)
• Headache
• Syncope (fainting)
• Anemia

Safety Measures

• Alcohol - Alcohol may increase the hypotensive effects of this medication; use with caution and avoid excessive consumption.
• Pregnancy - Contraindicated in pregnancy due to potential fetal harm (renal dysfunction, oligohydramnios, fetal death).
• Breastfeeding - Not recommended during breastfeeding as it may pass into breast milk and harm the infant.
• Liver - Use with caution in patients with mild to moderate hepatic impairment; not recommended in severe hepatic impairment.
• Kidney - Requires dose adjustment in patients with moderate to severe renal impairment; monitor kidney function closely.
• Lung - Generally safe for use in patients with lung conditions, but monitor for cough, a known side effect.

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