About
Sacubitril/Valsartan is a groundbreaking combination medication specifically designed for the treatment of chronic heart failure with reduced ejection fraction (HFrEF). Its unique mechanism involves a dual action: sacubitril, a neprilysin inhibitor, enhances the beneficial natriuretic peptide system, which promotes vasodilation, natriuresis, and diuresis, thereby reducing cardiac strain. Concurrently, valsartan, an angiotensin receptor blocker (ARB), counteracts the detrimental effects of the renin-angiotensin-aldosterone system (RAAS), such as vasoconstriction and fluid retention. This synergistic approach effectively reduces cardiac workload, improves myocardial function, and significantly lowers the risk of cardiovascular mortality and heart failure hospitalizations. It represents a critical advancement in the management of HFrEF, offering substantial clinical benefits and improving the prognosis for eligible patients.
Uses
- Chronic heart failure with reduced ejection fraction.
- To reduce the risk of cardiovascular death.
- To reduce the risk of heart failure hospitalization.
- Management of symptomatic chronic heart failure.
Directions For Use
Take orally as directed by your physician, usually twice daily. May be taken with or without food.
Benefits
- Significantly reduces cardiovascular mortality.
- Decreases hospitalizations due to heart failure.
- Improves symptoms of heart failure.
- Enhances quality of life for heart failure patients.
- Offers a novel mechanism of action for heart failure.
- Provides comprehensive RAAS blockade and natriuretic peptide system enhancement.
Side Effects
- Hypotension (low blood pressure)
- Hyperkalemia (high potassium levels)
- Renal impairment (kidney problems)
- Angioedema (swelling under the skin)
- Dizziness
- Cough
- Fatigue
- Nausea
- Diarrhea
- Anemia
- Hypoglycemia (in diabetics)
- Syncope (fainting)
Safety Measures
- Alcohol - Alcohol may exacerbate hypotension; use with caution and limit intake.
- Pregnancy - Contraindicated in pregnancy due to potential fetal harm (renal dysfunction, oligohydramnios, fetal death).
- Breastfeeding - Not recommended during breastfeeding; consult a doctor.
- Liver - Use with caution in patients with mild to moderate hepatic impairment; not recommended in severe impairment.
- Kidney - Requires careful monitoring of renal function and potassium levels; dose adjustment may be necessary.
- Lung - Generally safe for lung conditions, but monitor for cough, a common side effect.
Disclaimer
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| Shop Location | Assam, India |
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