Azacitidine 100mg Injection

About

Azacitidine 100mg Injection is a pyrimidine nucleoside analog that functions as a hypomethylating agent. It works by being incorporated into DNA and RNA, leading to hypomethylation of DNA. This process helps to restore normal function to genes involved in cell differentiation and proliferation that may have been silenced by abnormal methylation in cancer cells. It also exerts direct cytotoxicity to abnormal hematopoietic cells in the bone marrow.

This medication is primarily used in the treatment of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) with MDS-related changes, where it helps to improve hematologic parameters, reduce transfusion dependence, and potentially prolong survival.

Uses

• Myelodysplastic syndromes (MDS)
• Acute myeloid leukemia (AML)
• Chronic myelomonocytic leukemia (CMML)
• Juvenile myelomonocytic leukemia (JMML)

Directions For Use

Administered subcutaneously or intravenously by a healthcare professional, typically in cycles as per treatment protocol.

Benefits

• Improves overall survival in MDS
• Delays progression to AML
• Reduces transfusion dependence
• Improves hematologic parameters
• Effective in elderly AML patients
• Well-established treatment option

Side Effects

• Nausea
• Vomiting
• Diarrhea
• Constipation
• Fatigue
• Fever
• Injection site reactions
• Anemia
• Thrombocytopenia
• Neutropenia
• Leukopenia
• Pneumonia

Safety Measures

• Alcohol - Avoid or limit alcohol, as it may exacerbate gastrointestinal side effects or liver toxicity.
• Pregnancy - Contraindicated during pregnancy due to potential fetal harm. Use effective contraception.
• Breastfeeding - Not recommended during breastfeeding due to the potential for serious adverse reactions in infants.
• Liver - Use with caution; monitor liver function closely. Dose adjustment may be needed in severe impairment.
• Kidney - Use with caution; monitor renal function closely. Dose adjustment may be needed in severe impairment.
• Lung - Monitor for signs of pulmonary toxicity, including interstitial lung disease or pneumonitis.

Disclaimer

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