Celstrol 160mg Tablet

About

Celstrol 160mg Tablet contains a synthetic progestin, primarily used in oncology for its antineoplastic and appetite-stimulating properties. Its exact mechanism of action in cancer treatment is not fully understood but is thought to involve anti-estrogenic effects, particularly in hormone-sensitive cancers. It may also directly inhibit tumor growth by altering cellular differentiation and proliferation pathways. In patients with advanced cancer, Celstrol is often utilized to manage cachexia and anorexia, significantly improving appetite and promoting weight gain, thereby enhancing quality of life.

Administered orally, Celstrol is well-absorbed and metabolized in the liver. Its therapeutic effects are dose-dependent, with higher doses typically used for antineoplastic purposes and lower doses for appetite stimulation. Due to its hormonal nature, it can influence various endocrine systems, necessitating careful patient selection and monitoring for potential side effects, including thromboembolic events and adrenal suppression. It is an important palliative care agent in advanced disease settings.

Uses

• Treatment of advanced breast cancer
• Management of advanced endometrial cancer
• Appetite stimulation in AIDS-related cachexia
• Appetite stimulation in cancer-related anorexia/cachexia

Directions For Use

Take Celstrol 160mg Tablet orally, usually once daily, with or without food, as directed by your physician. Do not crush or chew the tablet.

Benefits

• Helps in managing hormone-sensitive cancers
• Significantly improves appetite in cachectic patients
• Promotes weight gain in individuals with anorexia
• Enhances overall quality of life in advanced disease
• Reduces tumor progression in specific cancers
• Offers palliative relief from cancer-related symptoms

Side Effects

• Weight gain (often desired in cachexia)
• Thromboembolic events (blood clots)
• Fluid retention (edema)
• Breakthrough uterine bleeding
• Adrenal suppression (with long-term use)
• Nausea and vomiting
• Diarrhea or constipation
• Rash
• Hot flashes
• Headache
• Insomnia
• Hypertension

Safety Measures

• Alcohol - Moderate alcohol consumption is generally not contraindicated, but excessive intake may exacerbate potential liver effects.
• Pregnancy - Celstrol is contraindicated in pregnancy due to potential harm to the fetus. Use effective contraception during treatment.
• Breastfeeding - Not recommended during breastfeeding as it may pass into breast milk and affect the infant or suppress lactation.
• Liver - Use with caution in patients with severe hepatic impairment; monitor liver function tests regularly.
• Kidney - No specific dose adjustment is typically required for renal impairment, but caution is advised in severe cases.
• Lung - Monitor for signs of thromboembolic events, including pulmonary embolism, especially in patients with risk factors.

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