Megahenz 160mg Tablet

About

Megestrol acetate is a synthetic progestin hormone, a derivative of progesterone, primarily utilized for its multifaceted therapeutic applications. In oncology, it plays a crucial role in the palliative treatment of advanced hormone-sensitive cancers, specifically advanced breast and endometrial carcinomas, by modulating hormone receptors and influencing tumor growth. Beyond its antineoplastic effects, megestrol acetate is widely recognized for its potent appetite-stimulating properties. This makes it an invaluable agent in managing cachexia, anorexia, and significant unexplained weight loss associated with debilitating conditions such as AIDS and various advanced cancers. Its mechanism in appetite stimulation is thought to involve complex interactions with cytokine pathways and hypothalamic centers regulating hunger and satiety, thereby improving nutritional status and enhancing the overall quality of life for patients experiencing wasting syndromes.

Uses

• Palliative treatment of advanced breast cancer.
• Palliative treatment of advanced endometrial cancer.
• Management of anorexia, cachexia, or unexplained significant weight loss in AIDS patients.
• Appetite stimulation in patients with cancer-related cachexia.

Directions For Use

Take this medicine exactly as prescribed by your doctor, usually once daily. It can be taken with or without food.

Benefits

• Helps manage advanced hormone-sensitive cancers.
• Significantly improves appetite.
• Promotes weight gain in cachectic patients.
• Enhances quality of life for patients with wasting syndromes.
• Reduces symptoms associated with advanced cancer.
• Available in convenient oral tablet form.

Side Effects

• Weight gain
• Nausea
• Vomiting
• Diarrhea
• Constipation
• Rash
• Hot flashes
• Fluid retention (edema)
• Thromboembolic events (blood clots)
• Adrenal suppression
• Breakthrough bleeding
• Headache

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may exacerbate certain side effects or interact with the medication.
• Pregnancy - Contraindicated in pregnancy due to potential harm to the fetus. Use effective contraception during treatment.
• Breastfeeding - Not recommended during breastfeeding as it may pass into breast milk and harm the infant.
• Liver - Use with caution in patients with liver impairment; dose adjustments and monitoring may be necessary.
• Kidney - Use with caution in patients with kidney impairment; dose adjustments may be required.
• Lung - Generally safe for lung conditions, but monitor for any new or worsening respiratory symptoms.

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