Cravihenz 40mg Tablet

About

Rosuvastatin is a highly efficacious HMG-CoA reductase inhibitor, commonly known as a statin, prescribed for the management of elevated cholesterol levels and the prevention of cardiovascular disease. It functions by competitively inhibiting the enzyme HMG-CoA reductase, which is a rate-limiting step in cholesterol biosynthesis within the liver. This inhibition leads to a significant reduction in the production of endogenous cholesterol, consequently increasing the uptake and catabolism of LDL-C ("bad" cholesterol) from the bloodstream. The therapeutic outcome is a substantial decrease in LDL-C, total cholesterol, and triglycerides, alongside a beneficial increase in HDL-C ("good" cholesterol). By improving the overall lipid profile, rosuvastatin plays a critical role in both the primary and secondary prevention of major cardiovascular events, such as myocardial infarction and stroke, especially in individuals identified as being at high cardiovascular risk due to dyslipidemia.

Uses

• Reduction of elevated total cholesterol and LDL-C.
• Treatment of primary hypercholesterolemia.
• Prevention of cardiovascular events in high-risk patients.
• Management of mixed dyslipidemia.

Directions For Use

Take one tablet orally once daily, with or without food, preferably at the same time each day.

Benefits

• Significantly lowers LDL-C.
• Reduces risk of heart attack and stroke.
• Increases beneficial HDL-C.
• Effective in managing various lipid disorders.
• Once-daily dosing for convenience.
• Well-established cardiovascular benefits.

Side Effects

• Muscle pain (myalgia)
• Headache
• Nausea
• Abdominal pain
• Weakness (asthenia)
• Dizziness
• Constipation
• Diarrhea
• Elevated liver enzymes (rare)
• Rhabdomyolysis (very rare, severe muscle breakdown)
• Memory loss or confusion (rare)
• New-onset diabetes (rare)

Safety Measures

• Alcohol - Limit alcohol intake as excessive consumption can increase the risk of liver problems, which statins can also affect.
• Pregnancy - Contraindicated in pregnancy due to potential for fetal harm. Effective contraception is required for women of childbearing potential.
• Breastfeeding - Contraindicated during breastfeeding as it is excreted in breast milk and could harm the infant.
• Liver - Contraindicated in active liver disease or unexplained persistent elevations of serum transaminases. Monitor liver function tests.
• Kidney - Use with caution in severe renal impairment; dose adjustments may be necessary as rosuvastatin is primarily excreted unchanged in the feces, but renal impairment can affect systemic exposure.
• Lung - No specific contraindications or known adverse effects on lung conditions. Rarely, interstitial lung disease has been reported with statins.

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