Megahenz 40mg Tablet

About

Megahenz 40mg Tablet contains megestrol acetate, a synthetic progestin with both hormonal and antineoplastic properties. It is primarily utilized in clinical settings for its ability to stimulate appetite and promote weight gain in patients experiencing cachexia or anorexia, particularly those with advanced cancer or AIDS-related wasting syndrome. The exact mechanism for appetite stimulation is not fully understood but is thought to involve modulation of cytokine production and direct effects on hypothalamic appetite centers. Additionally, megestrol acetate is employed in the palliative treatment of advanced breast and endometrial carcinomas, where its anti-estrogenic and progestational effects can inhibit tumor growth. Its therapeutic role focuses on improving quality of life and managing symptoms associated with severe weight loss and certain hormone-sensitive cancers.

Uses

• Appetite stimulation in cachexia/anorexia.
• Palliative treatment of advanced breast cancer.
• Palliative treatment of advanced endometrial cancer.
• Weight gain in patients with AIDS-related wasting.

Directions For Use

Take this tablet orally, usually once daily, as directed by your physician. Do not crush or chew the tablet; swallow it whole.

Benefits

• Increases appetite and food intake.
• Promotes significant weight gain.
• Improves quality of life in advanced illness.
• Reduces symptoms of anorexia and wasting.
• Offers palliative relief in certain cancers.
• Convenient oral administration.

Side Effects

• Weight gain
• Nausea
• Vomiting
• Diarrhea
• Constipation
• Flatulence
• Rash
• Hot flashes
• Headache
• Insomnia
• Fluid retention
• Thromboembolic events (rare)

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may exacerbate gastrointestinal side effects or increase liver strain.
• Pregnancy - Contraindicated during pregnancy as it can cause fetal harm and adverse developmental effects.
• Breastfeeding - Not recommended for use during breastfeeding as megestrol acetate may pass into breast milk and potentially harm the infant.
• Liver - Use with caution in patients with hepatic impairment; monitor liver function tests regularly.
• Kidney - Use with caution in patients with severe renal impairment; dosage adjustments may be necessary.
• Lung - Generally considered safe for use in patients with lung conditions; no specific contraindications.

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