Celtax 300mg Injection

About

Celtax Injection is an antineoplastic agent belonging to the taxane class of chemotherapy drugs. It exerts its cytotoxic effects by interfering with the normal function of microtubules, which are essential for cell division. Specifically, Celtax stabilizes microtubules, preventing their depolymerization and thus arresting cells in the G2/M phase of the cell cycle. This leads to the inhibition of cell proliferation and ultimately induces apoptosis in rapidly dividing cancer cells. Its mechanism of action makes it effective against a wide range of solid tumors.

Administered intravenously, Celtax is metabolized primarily in the liver and excreted through bile. Due to its potent cytotoxic nature, its administration requires careful monitoring by oncology specialists to manage potential adverse effects and ensure optimal therapeutic outcomes. The dosage and frequency are tailored based on the specific cancer type, stage, patient's body surface area, and overall health status, often as part of a multi-drug chemotherapy regimen.

Uses

• Treatment of breast cancer
• Management of non-small cell lung cancer
• Therapy for ovarian cancer
• Used in certain types of prostate cancer

Directions For Use

Celtax Injection is administered intravenously by a qualified healthcare professional in a clinical setting. Dosage and infusion rate are determined by the physician.

Benefits

• Effectively slows down cancer cell growth
• Induces apoptosis in malignant cells
• Can reduce tumor size
• Improves progression-free survival in various cancers
• Often used as a cornerstone in combination therapies
• May extend overall survival in eligible patients

Side Effects

• Bone marrow suppression (neutropenia, anemia, thrombocytopenia)
• Peripheral neuropathy (numbness, tingling)
• Alopecia (hair loss)
• Nausea and vomiting
• Diarrhea
• Muscle and joint pain (myalgia, arthralgia)
• Fatigue and weakness
• Hypersensitivity reactions (rash, flushing, dyspnea)
• Fluid retention (edema)
• Oral mucositis
• Nail changes
• Liver enzyme elevations

Safety Measures

• Alcohol - Avoid alcohol during Celtax treatment as it may exacerbate liver toxicity and gastrointestinal side effects.
• Pregnancy - Celtax is contraindicated in pregnancy due to significant risk of fetal harm. Effective contraception is essential for both male and female patients.
• Breastfeeding - Breastfeeding is not recommended during Celtax therapy and for a period after, as the drug may be excreted in breast milk and harm the infant.
• Liver - Use with caution in patients with hepatic impairment; dose adjustments may be necessary due to altered drug metabolism and increased toxicity risk.
• Kidney - Generally, no specific dose adjustment is required for mild to moderate renal impairment, but close monitoring is advised.
• Lung - Monitor for pulmonary toxicity, including interstitial pneumonitis, especially in patients with pre-existing lung conditions.

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