About
Atorvastatin is a highly effective HMG-CoA reductase inhibitor, commonly known as a statin. It functions by competitively inhibiting the enzyme HMG-CoA reductase, which plays a crucial role as the rate-limiting step in cholesterol biosynthesis within the liver. This inhibition leads to a substantial reduction in the liver's production of cholesterol. In response to lower intracellular cholesterol levels, the liver upregulates the expression of LDL receptors on its cell surfaces. This increased receptor activity enhances the uptake and catabolism of low-density lipoprotein cholesterol (LDL-C) from the bloodstream. The overall pharmacological effect is a significant reduction in total cholesterol, LDL-C, and triglycerides, alongside a modest increase in high-density lipoprotein cholesterol (HDL-C), thereby improving the lipid profile and reducing cardiovascular risk.
Uses
- Reduction of elevated total cholesterol, LDL-C, and triglycerides.
- Prevention of cardiovascular events in high-risk patients.
- Treatment of primary hypercholesterolemia and mixed dyslipidemia.
- Reduction of risk for myocardial infarction and stroke.
Directions For Use
Take once daily, preferably at the same time each day, with or without food, as directed by your doctor.
Benefits
- Significantly lowers bad cholesterol (LDL-C).
- Reduces triglyceride levels.
- Increases good cholesterol (HDL-C).
- Prevents heart attacks and strokes.
- Slows progression of atherosclerosis.
- Improves overall cardiovascular health.
Side Effects
- Muscle pain (myalgia)
- Joint pain (arthralgia)
- Headache
- Nausea
- Diarrhea
- Constipation
- Abdominal pain
- Insomnia
- Elevated liver enzymes
- Fatigue
- Rhabdomyolysis (rare, severe muscle breakdown)
- Memory impairment (rare)
Safety Measures
- Alcohol - Avoid excessive alcohol consumption, as it can increase the risk of liver damage, a potential side effect of statins.
- Pregnancy - Contraindicated during pregnancy due to potential harm to the fetus. Women of childbearing potential should use effective contraception.
- Breastfeeding - Contraindicated during breastfeeding as it may be excreted in breast milk and could harm the infant.
- Liver - Contraindicated in active liver disease or unexplained persistent elevations of serum transaminases. Liver function tests should be monitored.
- Kidney - No dose adjustment is generally required for renal impairment, but caution is advised in severe kidney disease.
- Lung - No specific contraindications related to lung conditions.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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