CLAVIX TAB 1

About

Clopidogrel is an antiplatelet agent that selectively inhibits the binding of adenosine diphosphate (ADP) to its specific receptor on the platelet surface. This inhibition prevents ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, which is essential for platelet aggregation. As a prodrug, clopidogrel requires hepatic metabolism, primarily by cytochrome P450 enzymes, to form its active thiol metabolite. This active metabolite then irreversibly modifies the platelet ADP receptor, leading to a sustained inhibition of platelet function for the lifespan of the platelet, typically 7-10 days. By preventing platelet aggregation, clopidogrel effectively reduces the formation of arterial blood clots, thereby significantly lowering the risk of serious atherothrombotic events such as myocardial infarction, stroke, and peripheral arterial disease in high-risk individuals.

Uses

• Prevention of atherothrombotic events in patients with myocardial infarction.
• Prevention of atherothrombotic events in patients with stroke.
• Prevention of atherothrombotic events in patients with established peripheral arterial disease.
• Prevention of stent thrombosis after percutaneous coronary intervention.

Directions For Use

Take once daily with or without food, as prescribed by your doctor. Do not stop taking it without medical advice.

Benefits

• Reduces risk of heart attack.
• Lowers risk of stroke.
• Prevents blood clot formation.
• Improves outcomes in peripheral artery disease.
• Reduces risk of stent thrombosis.
• Essential for post-cardiac procedure care.

Side Effects

• Bleeding (e.g., nosebleeds, bruising)
• Gastrointestinal upset
• Diarrhea
• Abdominal pain
• Headache
• Dizziness
• Rash
• Pruritus
• Thrombotic thrombocytopenic purpura (rare)
• Neutropenia (rare)
• Hemorrhagic stroke (rare)
• Liver enzyme elevation

Safety Measures

• Alcohol - Avoid excessive alcohol consumption as it can increase the risk of gastrointestinal bleeding, especially when combined with antiplatelet agents.
• Pregnancy - Use only if clearly necessary, as there are limited data on human pregnancy. Consult your doctor to weigh benefits against risks.
• Breastfeeding - It is unknown if clopidogrel is excreted in human milk. A decision should be made whether to discontinue nursing or the drug.
• Liver - Use with caution in patients with severe hepatic impairment, as clopidogrel is metabolized by the liver.
• Kidney - No dose adjustment is generally required for renal impairment, but caution is advised in severe kidney disease.
• Lung - No specific contraindications related to lung conditions.

Disclaimer

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