About
This medication contains Clozapine, an atypical antipsychotic primarily indicated for the treatment of severe, treatment-resistant schizophrenia in patients who have shown an inadequate response to at least two prior antipsychotic drugs. It is also uniquely approved for reducing the risk of recurrent suicidal behavior in patients diagnosed with schizophrenia or schizoaffective disorder. Clozapine exerts its therapeutic effects by modulating multiple neurotransmitter systems in the brain, notably dopamine D1, D2, D4, and serotonin 5-HT2A receptors, which helps to manage severe positive and negative psychotic symptoms and may improve cognitive function. Due to its distinct pharmacological profile, it can be highly effective where other treatments have failed. However, its use necessitates rigorous monitoring for potentially serious adverse effects, including agranulocytosis, myocarditis, and seizures, requiring a strict risk management program.
Uses
- Treatment-resistant schizophrenia.
- Schizophrenia with suicidal behavior.
- Schizoaffective disorder.
- Psychotic disorders (off-label).
Directions For Use
Take orally, usually once or twice daily, as prescribed by your doctor. Do not stop abruptly.
Benefits
- Effective for treatment-resistant schizophrenia.
- Reduces suicidal behavior risk.
- Improves positive and negative symptoms.
- May improve cognitive function.
- Lower risk of extrapyramidal side effects.
- Beneficial for severe aggression.
Side Effects
- Drowsiness
- Dizziness
- Constipation
- Weight gain
- Increased salivation
- Tachycardia
- Orthostatic hypotension
- Seizures
- Agranulocytosis (severe)
- Myocarditis (rare)
- Neuroleptic Malignant Syndrome (rare)
- Hyperglycemia
Safety Measures
- Alcohol - Avoid alcohol completely as it can increase sedation and other central nervous system depressant effects.
- Pregnancy - Consult a doctor; use only if clearly needed, as potential risks to the fetus exist.
- Breastfeeding - Not recommended, as clozapine passes into breast milk and may harm the infant.
- Liver - Use with extreme caution in patients with liver impairment; regular monitoring of liver function is essential.
- Kidney - Use with caution in patients with kidney impairment; dosage adjustment may be necessary.
- Lung - Use with caution in patients with severe respiratory conditions due to potential for respiratory depression.
Disclaimer
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| Shop Location | Assam, India |
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