About

Trimetazidine is a cellular anti-ischemic agent that improves myocardial glucose utilization through inhibition of fatty acid oxidation. It helps preserve energy metabolism in cells exposed to hypoxia or ischemia, thereby preventing a decrease in intracellular ATP levels. This action contributes to improved cardiac function and reduced symptoms in patients with stable angina pectoris. It does not directly affect hemodynamic parameters like heart rate or blood pressure, making it a useful add-on therapy for patients who are not adequately controlled by or intolerant to first-line anti-anginal treatments. Its mechanism focuses on metabolic rather than hemodynamic effects, offering a distinct approach to managing myocardial ischemia.

By optimizing cellular energy processes, trimetazidine enhances the efficiency of oxygen utilization within cardiac cells, particularly under conditions of reduced blood flow. This cytoprotective effect helps maintain cellular integrity and function, leading to clinical benefits such as increased exercise capacity and a reduction in the frequency and severity of angina attacks. It is often prescribed as a long-term treatment for stable angina.

Uses

Treatment of stable angina pectoris.
Adjunctive therapy for ischemic heart disease.
Management of vertigo and tinnitus of vascular origin.
Treatment of visual field disturbances of ischemic origin.

Directions For Use

Take orally as directed by your physician, usually with meals. Do not crush or chew extended-release tablets.

Benefits

Reduces frequency of angina attacks.
Improves exercise tolerance in angina patients.
Enhances myocardial energy metabolism.
Does not affect heart rate or blood pressure.
Can be used as add-on therapy.
May improve symptoms of vertigo and tinnitus.

Side Effects

Dizziness
Headache
Nausea
Vomiting
Diarrhea
Dyspepsia
Abdominal pain
Rash
Pruritus
Urticaria
Asthenia
Parkinsonian symptoms (rare)

Safety Measures

Alcohol - Alcohol consumption should be moderate as it may exacerbate dizziness or other central nervous system side effects.
Pregnancy - Not recommended during pregnancy due to insufficient data on human safety. Use only if clearly necessary and potential benefits outweigh risks.
Breastfeeding - It is unknown if trimetazidine is excreted in human milk. Breastfeeding is generally not recommended during treatment.
Liver - Use with caution in patients with moderate hepatic impairment. Dose adjustment may be necessary.
Kidney - Dose adjustment is required for patients with moderate to severe renal impairment. Not recommended for severe impairment.
Lung - Generally safe for use in patients with lung conditions, as it does not directly affect respiratory function.

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