About

Trimetazidine is a unique metabolic agent primarily utilized in cardiology for its anti-ischemic and cardioprotective properties, particularly in the management of angina pectoris. Its mechanism of action differs from traditional anti-anginal drugs as it does not directly affect hemodynamic parameters such as heart rate or blood pressure. Instead, trimetazidine acts by inhibiting the beta-oxidation of long-chain fatty acids, which in turn shifts myocardial energy metabolism towards glucose oxidation. Glucose oxidation is a more efficient process, requiring less oxygen to produce the same amount of adenosine triphosphate (ATP), the primary energy currency of cells. This metabolic reorientation helps to preserve cellular energy levels and maintain myocardial function under ischemic conditions, thereby protecting myocardial cells from the detrimental effects of oxygen deprivation. By optimizing energy utilization, trimetazidine effectively reduces the frequency and severity of angina attacks and improves exercise capacity in patients with stable angina, offering a valuable therapeutic option.

Uses

Prophylactic treatment of angina pectoris
Adjunctive therapy for vertigo of vascular origin
Adjunctive therapy for tinnitus of vascular origin
Improvement of visual field disturbances of vascular origin

Directions For Use

Take orally, usually once daily with a meal. Swallow the tablet whole; do not chew or crush to ensure controlled release.

Benefits

Reduces the frequency of angina attacks
Improves exercise capacity in angina patients
Enhances myocardial energy metabolism
Does not significantly affect heart rate or blood pressure
May improve symptoms of vertigo and tinnitus
Offers cardioprotective effects during ischemia

Side Effects

Dizziness
Headache
Nausea or vomiting
Abdominal pain
Diarrhea
Rash or itching
Asthenia (weakness)
Palpitations
Extrapyramidal symptoms (e.g., tremor, rigidity, gait instability)
Sleep disturbances
Orthostatic hypotension
Malaise

Safety Measures

Alcohol - No specific contraindication, but excessive alcohol intake can exacerbate dizziness or lightheadedness.
Pregnancy - Not recommended during pregnancy due to insufficient data. Consult a doctor.
Breastfeeding - Not recommended during breastfeeding as it is unknown if it is excreted in human milk. Consult a healthcare professional.
Liver - Use with caution in patients with moderate liver impairment. Dose adjustment may be considered.
Kidney - Contraindicated in patients with severe renal impairment (creatinine clearance < 30 mL/min). Dose adjustment is required for moderate impairment.
Lung - Generally considered safe for patients with lung conditions as it does not directly affect respiratory function.

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