METAGARD CR 60 TAB

AboutMETAGARD CR 60 TAB contains Trimetazidine, an anti-ischemic metabolic agent used in the treatment of angina pectoris. Unlike traditional anti-anginal drugs that primarily affect hemodynamics, Trimetazidine works by optimizing myocardial energy metabolism. It shifts the myocardial glucose oxidation pathway from fatty acid oxidation to glucose oxidation, which is more efficient in terms of oxygen consumption. This metabolic shift helps to preserve cellular energy levels (ATP) during periods of ischemia, thereby protecting cardiac cells from the damaging effects of reduced blood supply. By improving the efficiency of energy production, Trimetazidine enhances the heart's ability to function under ischemic conditions, reducing the frequency and severity of angina attacks. It is particularly useful as an add-on therapy for patients whose angina is not adequately controlled by first-line treatments or who cannot tolerate them. The controlled-release formulation ensures a sustained therapeutic effect, allowing for once or twice daily dosing.UsesTreatment of chronic stable angina pectoris.Adjunctive therapy for angina not controlled by other agents.Improvement of myocardial energy metabolism.Reduction in frequency of angina attacks.Directions For UseTake orally twice daily, with meals. Swallow the tablet whole; do not crush or chew.BenefitsReduces frequency and severity of angina attacks.Improves exercise tolerance in anginal patients.Optimizes myocardial energy metabolism.Acts independently of hemodynamic parameters.Can be used as add-on therapy.Controlled-release formulation for sustained effect.Side EffectsDizzinessHeadacheNauseaVomitingAbdominal painDiarrheaRashPruritusAstheniaPalpitationsExtrapyramidal symptoms (rare)Sleep disturbancesSafety MeasuresAlcohol - No specific contraindication, but excessive alcohol may worsen underlying cardiovascular conditions.Pregnancy - Not recommended due to insufficient data on human pregnancy. Consult a doctor.Breastfeeding - Not recommended. It is unknown if Trimetazidine passes into breast milk.Liver - Use with caution in patients with moderate liver impairment; severe impairment is a contraindication.Kidney - Use with caution in patients with moderate kidney impairment; severe impairment is a contraindication.Lung - Generally safe for use in patients with lung conditions; no direct respiratory effects.DisclaimerMedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.Our goal is to complement, not replace, the essential doctor-patient relationship.