Dasacad 20mg Tablet

About

Dasatinib is a potent, multi-targeted tyrosine kinase inhibitor (TKI) primarily used in the treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). It works by inhibiting the activity of several kinases, including BCR-ABL, SRC family kinases, c-KIT, EPHA2, and PDGFR-β. This inhibition prevents the proliferation of cancer cells that rely on these kinases for growth and survival. Its mechanism of action makes it effective against both imatinib-sensitive and imatinib-resistant forms of CML, offering a crucial therapeutic option for patients who have failed prior therapies or are newly diagnosed.

The drug is designed to bind to both active and inactive conformations of the BCR-ABL kinase, providing a broader inhibitory profile. This dual binding capability contributes to its efficacy in overcoming resistance mutations. Dasatinib is administered orally and is rapidly absorbed. Its targeted action helps to reduce the burden of malignant cells, leading to hematologic and cytogenetic responses in patients with these specific leukemias, thereby improving disease control and patient outcomes.

Uses

• Treatment of newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML).
• Treatment of Ph+ CML in chronic, accelerated, or myeloid/lymphoid blast phase with resistance or intolerance to prior therapy.
• Treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) with resistance or intolerance to prior therapy.
• Treatment of newly diagnosed Ph+ ALL.

Directions For Use

Take Dasacad 20mg Tablet orally once daily, with or without food, as prescribed by your doctor. Do not crush or cut the tablet.

Benefits

• Highly effective in treating specific types of leukemia.
• Offers a treatment option for patients resistant to other therapies.
• Improves remission rates in CML and Ph+ ALL.
• Can lead to significant cytogenetic and molecular responses.
• Administered orally for convenience.
• Targets multiple kinases for broad anti-cancer activity.

Side Effects

• Myelosuppression (anemia, neutropenia, thrombocytopenia)
• Fluid retention (pleural effusion, pericardial effusion, pulmonary edema)
• Diarrhea
• Nausea
• Fatigue
• Headache
• Rash
• Muscle pain
• Abdominal pain
• Hemorrhage
• QT prolongation
• Hypertension

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may exacerbate certain side effects like liver issues or gastrointestinal upset.
• Pregnancy - Dasatinib is contraindicated in pregnancy due to potential fetal harm. Effective contraception is required for women of childbearing potential.
• Breastfeeding - Breastfeeding is not recommended during treatment with Dasatinib and for a period after, as the drug may pass into breast milk and harm the infant.
• Liver - Use with caution in patients with hepatic impairment; dose adjustments may be necessary. Monitor liver function tests regularly.
• Kidney - Use with caution in patients with renal impairment. No specific dose adjustment is typically required, but close monitoring is advised.
• Lung - Monitor for signs of pulmonary hypertension or interstitial lung disease, especially in patients with pre-existing lung conditions.

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