Dasamac 70mg Tablet

About

Dasatinib is an oral tyrosine kinase inhibitor (TKI) primarily used in the treatment of certain types of leukemia. It works by blocking the activity of specific enzymes, known as tyrosine kinases, which are involved in the growth and proliferation of cancer cells. By inhibiting these kinases, dasatinib helps to slow or stop the progression of the disease. It is particularly effective against the Bcr-Abl fusion protein, a hallmark of chronic myeloid leukemia (CML) and some forms of acute lymphoblastic leukemia (ALL).

This medication is often prescribed when other TKI treatments have failed or are not tolerated, or as a first-line therapy in specific patient populations. Its targeted action helps to reduce the burden of cancerous cells, leading to improved hematologic and cytogenetic responses. Regular monitoring of blood counts and other parameters is crucial during treatment to assess efficacy and manage potential side effects, ensuring optimal patient outcomes.

Uses

• Treatment of newly diagnosed Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) in chronic phase.
• Treatment of Ph+ CML in chronic, accelerated, or myeloid or lymphoid blast phase with resistance or intolerance to prior therapy.
• Treatment of Ph+ acute lymphoblastic leukemia (ALL) with resistance or intolerance to prior therapy.
• Treatment of newly diagnosed Ph+ ALL in combination with chemotherapy.

Directions For Use

Take this medication orally, usually once daily, with or without food, as directed by your physician. Do not crush, cut, or chew the tablet; swallow it whole.

Benefits

• Highly effective in treating specific leukemias.
• Can be used as first-line or second-line therapy.
• Targets cancer cells with high specificity.
• Improves hematologic and cytogenetic responses.
• Available in oral tablet form for convenience.
• May extend progression-free and overall survival.

Side Effects

• Fluid retention (pleural effusion, peripheral edema)
• Myelosuppression (anemia, neutropenia, thrombocytopenia)
• Diarrhea
• Nausea
• Headache
• Fatigue
• Rash
• Dyspnea
• Musculoskeletal pain
• Hemorrhage
• Cardiac dysfunction (QT prolongation)
• Hypertension

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may exacerbate certain side effects like liver issues or gastrointestinal upset.
• Pregnancy - Dasatinib is contraindicated in pregnancy due to potential fetal harm. Effective contraception is required for women of childbearing potential.
• Breastfeeding - Breastfeeding is not recommended during treatment with dasatinib and for a period after the last dose, as the drug may pass into breast milk.
• Liver - Use with caution in patients with pre-existing liver impairment; dose adjustments may be necessary, and liver function should be monitored regularly.
• Kidney - Use with caution in patients with renal impairment; dose adjustments may be required, and kidney function should be monitored.
• Lung - Monitor for signs of pulmonary arterial hypertension or pleural effusion; prompt evaluation and management are necessary if these occur.

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