Dasania 50mg Tablet

About

Dasania 50mg Tablet belongs to a class of medications known as tyrosine kinase inhibitors (TKIs). It functions by selectively inhibiting the activity of specific enzymes, particularly BCR-ABL tyrosine kinase, which are crucial for the proliferation and survival of cancer cells in certain types of leukemia. By blocking these abnormal proteins, the medication helps to control the growth of cancerous cells and reduce their numbers in the body. This targeted action minimizes damage to healthy cells compared to traditional chemotherapy, leading to a more specific therapeutic effect.

This medication is primarily used in the treatment of chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL) that are Philadelphia chromosome-positive (Ph+). Its mechanism of action involves binding to and inhibiting the ATP-binding site of the BCR-ABL kinase, thereby preventing the phosphorylation of downstream signaling proteins essential for cell growth and division. This leads to apoptosis (programmed cell death) in leukemia cells, effectively managing the disease progression and improving patient outcomes.

Uses

• Treatment of newly diagnosed Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) in chronic phase.
• Treatment of Ph+ CML in chronic, accelerated, or myeloid/lymphoid blast phase with resistance or intolerance to prior therapy.
• Treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) with resistance or intolerance to prior therapy.
• Treatment of Ph+ ALL in adult patients who are newly diagnosed and cannot tolerate other TKI therapies.

Directions For Use

Take this medication orally, once daily, with or without food, as directed by your physician. Swallow the tablet whole; do not crush, cut, or chew it.

Benefits

• Effectively targets and inhibits cancer cell growth.
• Improves remission rates in specific leukemias.
• Offers a targeted therapy approach with fewer systemic side effects than traditional chemotherapy.
• Can be effective in patients resistant to other TKI treatments.
• Helps to prolong progression-free survival.
• Contributes to improved overall survival in eligible patients.

Side Effects

• Fatigue
• Nausea
• Diarrhea
• Headache
• Rash
• Fluid retention (edema)
• Myelosuppression (low blood counts)
• Muscle pain
• Abdominal pain
• Shortness of breath
• Bleeding events
• Infections

Safety Measures

• Alcohol - Alcohol consumption should be limited or avoided as it may exacerbate certain side effects or interact with the medication, potentially affecting liver function.
• Pregnancy - This medication is generally contraindicated during pregnancy due to potential harm to the fetus. Effective contraception is advised for women of childbearing potential.
• Breastfeeding - Breastfeeding is not recommended during treatment and for a period after the last dose, as the drug may pass into breast milk and harm the infant.
• Liver - Use with caution in patients with pre-existing liver impairment. Dose adjustments may be necessary, and liver function should be monitored regularly.
• Kidney - Caution is advised in patients with renal impairment. Dose adjustments may be required, and kidney function should be closely monitored.
• Lung - Patients should be monitored for pulmonary adverse events, including pleural effusion and pulmonary hypertension, especially with prolonged use.

Disclaimer

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