Daslemia 70mg Tablet

About

Daslemia 70mg Tablet, containing Dasatinib, is a potent oral tyrosine kinase inhibitor (TKI) primarily used in the treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). It works by inhibiting multiple kinases, including BCR-ABL, SRC family kinases, and others, which are crucial for the proliferation and survival of cancer cells. By blocking these aberrant signaling pathways, Dasatinib effectively suppresses the growth of malignant cells and induces apoptosis, leading to significant clinical responses in patients who are resistant or intolerant to other TKI therapies.

Taken orally once daily, Daslemia 70mg offers a convenient and effective therapeutic option for patients with specific forms of leukemia. Its broad spectrum of kinase inhibition contributes to its efficacy in overcoming resistance mechanisms that can develop with other TKIs. Regular monitoring of hematologic parameters and potential side effects, such as fluid retention and myelosuppression, is essential to ensure optimal patient management and safety. Dasatinib represents a significant advancement in targeted cancer therapy, improving progression-free and overall survival rates for eligible patients.

Uses

• Treatment of Chronic Myeloid Leukemia (CML)
• Management of Philadelphia chromosome-positive Acute Lymphoblastic Leukemia (Ph+ ALL)
• Used in imatinib-resistant CML
• Therapy for CML in chronic, accelerated, or blast phase

Directions For Use

Take orally once daily with or without food. Do not crush, cut, or chew the tablets.

Benefits

• Highly effective in CML and Ph+ ALL
• Overcomes imatinib resistance
• Provides rapid and durable responses
• Improves progression-free and overall survival
• Convenient oral administration
• Inhibits multiple oncogenic kinases

Side Effects

• Myelosuppression (thrombocytopenia, neutropenia, anemia)
• Fluid retention (pleural effusion, peripheral edema)
• Diarrhea
• Headache
• Fatigue
• Nausea
• Rash
• Dyspnea (shortness of breath)
• Hemorrhage
• QT prolongation
• Abdominal pain
• Musculoskeletal pain

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may exacerbate gastrointestinal side effects or increase liver strain.
• Pregnancy - Contraindicated during pregnancy due to potential for fetal harm. Effective contraception must be used by both male and female patients.
• Breastfeeding - Not recommended during breastfeeding as it is unknown if the drug is excreted in human milk, posing a risk to the infant.
• Liver - Use with caution in patients with hepatic impairment; monitor liver function tests regularly. Dose adjustment may be needed in severe impairment.
• Kidney - Use with caution in patients with renal impairment; no specific dose adjustment typically required for mild to moderate impairment, but monitor.
• Lung - Monitor for pulmonary arterial hypertension (PAH) and pleural effusions; may require dose interruption or discontinuation.

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