About

Doripik VAIL contains doripenem, a carbapenem antibiotic administered intravenously, known for its exceptionally broad spectrum of activity. It is a bactericidal agent that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death. Doripenem is highly effective against a wide range of Gram-positive, Gram-negative, and anaerobic bacteria, including many strains that produce extended-spectrum beta-lactamases (ESBLs), which are resistant to other beta-lactam antibiotics.

This medication is primarily indicated for the treatment of severe and complicated infections, such as complicated intra-abdominal infections, complicated urinary tract infections, and hospital-acquired pneumonia, including ventilator-associated pneumonia. Its robust activity against difficult-to-treat pathogens makes it a critical option in intensive care settings and for patients with serious, multi-drug resistant infections. Careful monitoring for adverse effects, particularly neurological ones, is important during therapy.

Uses

Treatment of complicated intra-abdominal infections (cIAI).
Management of complicated urinary tract infections (cUTI).
Therapy for hospital-acquired pneumonia (HAP).
Treatment of ventilator-associated pneumonia (VAP).

Directions For Use

Administer intravenously as directed by a healthcare professional. Dosage and duration depend on the infection's severity and patient response.

Benefits

Very broad spectrum of activity against diverse bacteria.
Effective against multi-drug resistant (MDR) pathogens, including ESBLs.
Rapid bactericidal action for severe infections.
Good penetration into various body tissues and fluids.
Suitable for critically ill patients in intensive care.
Lower potential for seizures compared to some other carbapenems.

Side Effects

Nausea
Diarrhea
Headache
Rash
Injection site reactions
Elevated liver enzymes
Seizures (rare)
C. difficile infection
Allergic reactions
Candidiasis
Anemia
Thrombocytopenia

Safety Measures

Alcohol - Concurrent alcohol consumption may exacerbate gastrointestinal side effects. It is generally advisable to avoid alcohol during treatment.
Pregnancy - Use during pregnancy should only be considered if the potential benefit outweighs the potential risk to the fetus. Consult a physician before use.
Breastfeeding - Small amounts may pass into breast milk. Use with caution and monitor the infant for adverse effects. Consult a healthcare provider.
Liver - Use with caution in patients with hepatic impairment. Dose adjustments may be necessary, and liver function should be monitored.
Kidney - Dose adjustments are typically required for patients with renal impairment. Close monitoring of kidney function is essential during therapy, as renal impairment increases seizure risk.
Lung - Generally safe for use in patients with lung conditions, but caution is advised in those with severe respiratory compromise or asthma due to potential allergic reactions.

Disclaimer

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