About
Tenofovir Alafenamide (TAF) is a novel prodrug of tenofovir, a nucleotide reverse transcriptase inhibitor (NtRTI), used for the treatment of human immunodeficiency virus (HIV) infection and chronic hepatitis B virus (HBV) infection. TAF is designed to deliver tenofovir more efficiently to target cells (lymphocytes and hepatocytes) at a lower dose compared to its predecessor, Tenofovir Disoproxil Fumarate (TDF).
This results in significantly lower systemic tenofovir exposure, leading to improved renal and bone safety profiles while maintaining potent antiviral efficacy. TAF is typically formulated as part of a fixed-dose combination with other antiretroviral agents for HIV or as a standalone treatment for chronic HBV, offering a safer and effective option for long-term management with reduced systemic side effects.
Uses
- Treatment of HIV-1 infection (in combination with other antiretrovirals).
- Treatment of chronic hepatitis B virus (HBV) infection.
- Reduction of HIV viral load.
- Prevention of liver damage due to HBV.
Directions For Use
Take orally once daily with food. Follow your doctor's instructions precisely and do not interrupt treatment.
Benefits
- Potent antiviral activity against HIV and HBV.
- Improved renal safety profile compared to TDF.
- Better bone mineral density outcomes than TDF.
- Effective at lower doses, reducing systemic exposure.
- Convenient once-daily dosing.
- Part of recommended first-line treatment regimens.
Side Effects
- Nausea
- Diarrhea
- Headache
- Abdominal pain
- Fatigue
- Flatulence
- Increased liver enzymes
- Rash
- Vomiting
- Dizziness
- Insomnia
- Weight gain (less common but noted)
Safety Measures
- Alcohol - Avoid or limit alcohol consumption as it can worsen liver disease and potentially increase the risk of side effects.
- Pregnancy - Generally considered safe for use during pregnancy, but discuss risks and benefits with your doctor.
- Breastfeeding - Not recommended due to potential for HIV transmission and drug excretion into breast milk.
- Liver - Use with caution in patients with severe hepatic impairment; regular monitoring of liver function is essential.
- Kidney - Generally safer for kidneys than TDF, but caution and monitoring are still advised in severe renal impairment.
- Lung - No specific contraindications or precautions related to lung conditions are generally noted for this medication.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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