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About

Sofosbuvir is a direct-acting antiviral (DAA) medication primarily used in the treatment of chronic hepatitis C virus (HCV) infection. It is a nucleotide analog NS5B polymerase inhibitor, meaning it directly targets and inhibits the RNA polymerase enzyme that the hepatitis C virus uses to replicate its genetic material. Sofosbuvir is highly effective across multiple HCV genotypes and forms the backbone of many interferon-free, all-oral treatment regimens.

It is almost always used in combination with other DAAs, such as ledipasvir, velpatasvir, or daclatasvir, to achieve high sustained virologic response (SVR) rates, often leading to a cure for HCV infection. Its introduction revolutionized HCV treatment, offering shorter treatment durations and fewer side effects compared to older therapies, significantly improving patient outcomes and quality of life.

Uses

• Treatment of chronic hepatitis C virus (HCV) infection.
• Used in combination with other direct-acting antivirals.
• Effective across various HCV genotypes.
• Achieving sustained virologic response (SVR) in HCV patients.

Directions For Use

Take orally once daily with or without food, as prescribed by your specialist. Complete the entire course of therapy.

Benefits

• High cure rates for hepatitis C infection.
• Shorter treatment durations compared to older therapies.
• Well-tolerated with fewer side effects.
• Effective across multiple HCV genotypes.
• Significantly reduces the risk of liver complications.
• Offers an all-oral, interferon-free treatment option.

Side Effects

• Headache
• Fatigue
• Nausea
• Insomnia
• Diarrhea
• Irritability
• Rash
• Anemia (when used with ribavirin)
• Bradycardia (when used with amiodarone)
• Dizziness
• Muscle pain
• Dyspepsia

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it can worsen liver disease and potentially interfere with treatment efficacy.
• Pregnancy - Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult your doctor.
• Breastfeeding - It is unknown if sofosbuvir is excreted in human milk. Discuss with your healthcare provider.
• Liver - Used to treat liver disease; however, caution is advised in patients with severe hepatic impairment.
• Kidney - Dosage adjustment may be required for severe renal impairment or end-stage renal disease.
• Lung - No specific contraindications or precautions related to lung conditions are generally noted for this medication.

Disclaimer

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