HEPCINAT 400 MG TAB. 1X28 TAB.

About

Sofosbuvir is a direct-acting antiviral medication specifically designed for the treatment of chronic hepatitis C virus (HCV) infection. It functions as a nucleotide analog NS5B polymerase inhibitor, targeting a key enzyme essential for HCV replication. By inhibiting this enzyme, sofosbuvir effectively blocks the virus's ability to multiply within liver cells, leading to a significant reduction in viral load and, in many cases, a sustained virologic response. It is typically used in combination with other antiviral agents to achieve optimal treatment outcomes across various HCV genotypes.

This medication represents a cornerstone in modern HCV therapy, offering high cure rates and a generally favorable safety profile compared to older interferon-based regimens. Its introduction has revolutionized the management of hepatitis C, providing a more tolerable and effective treatment option for a broad range of patients, including those with compensated cirrhosis. The treatment duration and specific combination therapy depend on the patient's HCV genotype, prior treatment history, and liver disease status.

Uses

• Treatment of chronic hepatitis C virus (HCV) infection.
• Used in combination with other antiviral agents.
• Effective across multiple HCV genotypes.
• For patients with or without compensated cirrhosis.

Directions For Use

Take orally once daily with or without food, as directed by your physician. Do not crush or chew the tablet.

Benefits

• High sustained virologic response (SVR) rates.
• Directly targets HCV replication.
• Improved tolerability compared to older therapies.
• Shorter treatment durations in many cases.
• Effective across various HCV genotypes.
• Reduces risk of liver complications.

Side Effects

• Headache
• Fatigue
• Nausea
• Insomnia
• Diarrhea
• Anemia
• Irritability
• Rash
• Pruritus
• Muscle pain
• Dyspnea
• Decreased appetite

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it can worsen liver disease and potentially interfere with treatment efficacy.
• Pregnancy - Not recommended during pregnancy unless the potential benefit outweighs the risk; use effective contraception.
• Breastfeeding - It is unknown if sofosbuvir passes into breast milk; caution is advised, and a physician should be consulted.
• Liver - Generally safe for use in patients with compensated liver disease; close monitoring is required for decompensated cirrhosis.
• Kidney - Dose adjustment may be necessary for severe renal impairment (eGFR <30 mL/min/1.73 m²); not recommended for ESRD.
• Lung - No specific contraindications related to lung conditions; use with caution in patients with pre-existing respiratory issues.

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