About

Heparin is a rapidly acting anticoagulant that inhibits various factors in the coagulation cascade, primarily by potentiating the action of antithrombin III. It is a heterogeneous mixture of sulfated mucopolysaccharides that binds to antithrombin III, causing a conformational change that greatly enhances its ability to inactivate thrombin (Factor IIa) and Factor Xa. This action prevents the formation of new clots and the extension of existing ones, making it crucial in the management of various thrombotic conditions. Its onset of action is almost immediate following intravenous administration, and it has a relatively short half-life, necessitating frequent dosing or continuous infusion. The anticoagulant effect is dose-dependent and requires careful monitoring to prevent bleeding complications. Heparin does not lyse existing clots but prevents their growth.

Uses

Prevention and treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE).
Prevention of clotting in arterial and cardiac surgery.
Anticoagulation during hemodialysis and extracorporeal circulation.
Prevention of perioperative thromboembolism.

Directions For Use

Administer as directed by a healthcare professional, typically via intravenous or subcutaneous injection. Dosage is individualized based on patient weight and coagulation parameters.

Benefits

Rapid onset of anticoagulant action.
Effective in preventing clot formation.
Reduces risk of thromboembolic events.
Reversible with protamine sulfate.
Widely used in critical care settings.
Prevents extension of existing clots.

Side Effects

Bleeding (hemorrhage)
Thrombocytopenia (HIT)
Osteoporosis (long-term use)
Hypersensitivity reactions
Injection site pain/bruising
Elevated liver enzymes
Alopecia (rare)
Priapism (rare)
Hyperkalemia
Skin necrosis
Chills
Fever

Safety Measures

Alcohol - Avoid or limit alcohol consumption as it may increase the risk of bleeding when combined with heparin.
Pregnancy - Generally considered safe for use during pregnancy as it does not cross the placenta. Close monitoring is advised.
Breastfeeding - Heparin is not excreted into breast milk in significant amounts and is generally considered safe during breastfeeding.
Liver - Use with caution in patients with severe liver impairment due to increased risk of bleeding; dose adjustment may be necessary.
Kidney - Use with caution in patients with severe renal impairment as it may prolong half-life and increase bleeding risk; dose adjustment may be necessary.
Lung - No specific contraindications related to lung conditions, but caution is advised in patients with conditions predisposing to bleeding.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.

Shipping & Location