About
This medication combines Empagliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, and Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor. Empagliflozin works by blocking the reabsorption of glucose in the kidneys, leading to increased glucose excretion in the urine and thus lowering blood sugar levels. It also offers cardiovascular and renal benefits. Sitagliptin enhances the body's natural ability to lower high blood sugar levels by increasing the levels of incretin hormones, which stimulate insulin release and decrease glucagon secretion in a glucose-dependent manner. This dual-action approach provides comprehensive glycemic control for adults with type 2 diabetes, particularly when monotherapy is insufficient. The combination helps to improve HbA1c, fasting plasma glucose, and postprandial glucose levels, contributing to better long-term diabetes management and reducing the risk of associated complications.
Uses
- Management of type 2 diabetes mellitus in adults.
- To improve glycemic control when diet and exercise are insufficient.
- As an add-on therapy to other antidiabetic medications.
- To reduce the risk of cardiovascular death in patients with type 2 diabetes and established cardiovascular disease.
Directions For Use
Take one tablet orally once daily, with or without food, as directed by your physician.
Benefits
- Provides comprehensive blood sugar control.
- Reduces HbA1c levels effectively.
- Offers cardiovascular protective benefits.
- May support weight management.
- Low risk of hypoglycemia when used alone.
- Convenient once-daily dosing.
Side Effects
- Urinary tract infections
- Genital yeast infections
- Increased urination
- Nausea
- Diarrhea
- Headache
- Joint pain
- Runny nose or sore throat
- Hypoglycemia (when used with insulin or sulfonylureas)
- Ketoacidosis (rare)
- Pancreatitis (rare)
- Serious allergic reactions
Safety Measures
- Alcohol - Moderate alcohol intake is generally acceptable, but excessive consumption may increase the risk of hypoglycemia or lactic acidosis. Consult your doctor.
- Pregnancy - Not recommended during pregnancy. Consult your doctor immediately if you become pregnant or plan to conceive.
- Breastfeeding - It is unknown if components pass into breast milk. Avoid during breastfeeding or consult your doctor for advice.
- Liver - Use with caution in patients with mild to moderate hepatic impairment. Not recommended in severe liver disease.
- Kidney - Dose adjustment may be required based on kidney function. Not recommended in severe renal impairment or end-stage renal disease.
- Lung - Generally safe for use in patients with lung conditions. No specific contraindications related to lung function.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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