GLUXIT 10MG TAB 10 S

About

Dapagliflozin is an oral antidiabetic medication belonging to the class of sodium-glucose co-transporter 2 (SGLT2) inhibitors. It works by inhibiting SGLT2 in the kidneys, which is responsible for reabsorbing glucose from the filtered blood back into the bloodstream. By blocking SGLT2, dapagliflozin causes the kidneys to excrete more glucose in the urine, thereby lowering blood glucose levels independently of insulin secretion or sensitivity. This mechanism also leads to osmotic diuresis, contributing to a modest reduction in blood pressure and weight loss.

Beyond its glucose-lowering effects, dapagliflozin has demonstrated significant cardiovascular and renal benefits in patients with type 2 diabetes, including a reduced risk of major adverse cardiovascular events, hospitalization for heart failure, and progression of chronic kidney disease. It is typically used as an adjunct to diet and exercise, either as monotherapy or in combination with other antidiabetic agents, to improve glycemic control in adults with type 2 diabetes mellitus.

Uses

• To improve glycemic control in adults with type 2 diabetes mellitus.
• To reduce the risk of cardiovascular death and hospitalization for heart failure in adults with type 2 diabetes and established cardiovascular disease or multiple cardiovascular risk factors.
• To reduce the risk of hospitalization for heart failure in adults with heart failure with reduced ejection fraction.
• To reduce the risk of sustained eGFR decline, end-stage kidney disease, cardiovascular death, and hospitalization for heart failure in adults with chronic kidney disease.

Directions For Use

Take orally once daily, preferably in the morning, with or without food. Follow your doctor's prescribed dosage and regimen.

Benefits

• Effectively lowers blood glucose levels.
• Reduces the risk of cardiovascular events.
• Provides protection against heart failure hospitalization.
• Slows the progression of chronic kidney disease.
• Contributes to modest weight loss.
• Can lower blood pressure slightly.

Side Effects

• Genital yeast infections
• Urinary tract infections
• Increased urination
• Thirst
• Nausea
• Back pain
• Flu-like symptoms
• Dizziness
• Hypoglycemia (when used with insulin or sulfonylureas)
• Ketoacidosis (rare)
• Fournier's gangrene (very rare)
• Dehydration

Safety Measures

• Alcohol - Limit alcohol intake as it can increase the risk of hypoglycemia, especially when combined with other antidiabetic medications, and may contribute to dehydration.
• Pregnancy - Not recommended during the second and third trimesters due to potential adverse effects on fetal kidney development. Use only if clearly needed and benefits outweigh risks.
• Breastfeeding - Not recommended during breastfeeding as it is unknown if dapagliflozin is excreted in human milk and could pose risks to the infant.
• Liver - Generally safe for use in mild to moderate hepatic impairment; however, caution is advised in severe liver disease as drug exposure may be increased.
• Kidney - Dosage adjustment may be necessary based on estimated glomerular filtration rate (eGFR). Not recommended for initiation in patients with eGFR below 25 mL/min/1.73 m².
• Lung - No specific contraindications or dose adjustments related to lung conditions. However, ensure adequate hydration to prevent complications.

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