About

This medication is a fixed-dose combination oral antidiabetic agent indicated for the management of type 2 diabetes mellitus in adults. It combines dapagliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, with metformin, a biguanide. Dapagliflozin works by inhibiting SGLT2 in the kidneys, which reduces glucose reabsorption and increases glucose excretion in the urine, thereby lowering blood glucose levels. Metformin primarily acts by decreasing hepatic glucose production and improving insulin sensitivity in peripheral tissues, leading to enhanced glucose uptake and utilization. The combination provides complementary mechanisms of action to achieve comprehensive glycemic control, particularly when diet and exercise alone are insufficient.

Uses

Treatment of type 2 diabetes mellitus.
As an adjunct to diet and exercise.
To improve glycemic control.
When monotherapy is insufficient.

Directions For Use

Take orally as prescribed by your doctor, usually twice daily with meals to reduce gastrointestinal side effects.

Benefits

Effective reduction in HbA1c.
Supports weight management.
Provides cardiovascular benefits.
Offers renal protective effects.
Improves insulin sensitivity.
Lower risk of hypoglycemia compared to sulfonylureas.

Side Effects

Genital yeast infections
Urinary tract infections
Increased urination
Nausea and diarrhea
Abdominal discomfort
Metallic taste
Headache
Dizziness
Fatigue
Back pain
Rarely, lactic acidosis
Vitamin B12 deficiency

Safety Measures

Alcohol - Avoid excessive alcohol intake due to an increased risk of lactic acidosis with metformin.
Pregnancy - Not recommended during pregnancy; consult your doctor for alternative treatment options.
Breastfeeding - Avoid during breastfeeding as components may pass into breast milk; seek medical advice.
Liver - Use with caution in patients with liver impairment; contraindicated in severe hepatic dysfunction due to metformin.
Kidney - Contraindicated in severe renal impairment; dose adjustment required for moderate impairment.
Lung - Generally safe, but monitor for any signs of respiratory distress, especially if lactic acidosis is suspected.

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