About

This medication contains dapagliflozin, a selective sodium-glucose co-transporter 2 (SGLT2) inhibitor, indicated for the management of type 2 diabetes mellitus in adults. It works independently of insulin secretion by inhibiting SGLT2 in the renal tubules, which is responsible for reabsorbing most of the filtered glucose back into the bloodstream. By blocking SGLT2, dapagliflozin reduces glucose reabsorption, leading to increased urinary glucose excretion and a subsequent reduction in blood glucose levels. This mechanism also results in osmotic diuresis, contributing to modest weight loss and blood pressure reduction. Dapagliflozin has demonstrated cardiovascular and renal benefits in patients with type 2 diabetes.

Uses

Treatment of type 2 diabetes mellitus.
As an adjunct to diet and exercise.
To improve glycemic control.
To reduce risk of cardiovascular events.

Directions For Use

Take orally once daily, preferably in the morning, with or without food, as directed by your physician.

Benefits

Effective reduction in HbA1c.
Supports weight loss.
Provides cardiovascular benefits.
Offers renal protective effects.
Low risk of hypoglycemia.
Contributes to blood pressure reduction.

Side Effects

Genital yeast infections
Urinary tract infections
Increased urination frequency
Dehydration
Hypotension
Dizziness
Back pain
Nausea
Fatigue
Flu-like symptoms
Rarely, ketoacidosis
Rarely, Fournier's gangrene

Safety Measures

Alcohol - Limit alcohol intake as it may increase the risk of dehydration and, rarely, ketoacidosis.
Pregnancy - Not recommended during pregnancy, especially in the second and third trimesters; consult your doctor.
Breastfeeding - Avoid during breastfeeding as it may be excreted in breast milk; seek medical advice.
Liver - Use with caution in patients with liver impairment; dose adjustment may be necessary.
Kidney - Contraindicated in severe renal impairment; not recommended for use in patients with eGFR below 45 mL/min/1.73 m².
Lung - Generally safe, but monitor for signs of dehydration which could impact respiratory function in vulnerable patients.

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